Goto-Kakizaki

Inbred

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CALL: 888.822.6642 + 45 70 23 04 05 (EUROPE)

Available for immediate cryorecovery.

Model #
Genotype
Nomenclature

GK

GK/MolTac

Model Description

A non-obese model of Non-Insulin Dependent Diabetes Mellitus (NIDDM), type II diabetes.
It exhibits similar metabolic, hormonal, and vascular disorders to the human diabetes disease.
Males develop type II diabetes at approximately 14 - 16 weeks of age.
Characteristics include fasting hyperglycemia, impaired secretion of insulin in response to glucose both in vivo and in isolated pancreatic cells, hepatic and peripheral insulin resistance and polyuria
Late complications such as retinopathy, microangiopathy, neuropathy, and nephropathy have been described in literature
Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.
The GK colony was derived from inbred stock and was bred randomly in a closed colony.

Origin:

The Goto-Kakizaki inbred model was developed by Tohoku University in 1975. Aarhus University Hospital in Denmark received stock in 1994. M&B A/S (now Taconic Europe) received stock from Aarhus in 1997. The rats were derived by embryo transfer in 2005 at Taconic US.

Genetics:

Strain Profile: Aco1^b, Alp^a, Amy2^a, Anpep^a, Es1^a, Es2^a, Es3^a, Es4^a, Es4^b, Es6^a, Es7^b, Es9^a, Esd^a, Es14^b, Es15^a, Es18^a, Fh1^b, Hao1^a, Hbb^a, Pepc^b, Pgd1^b, Svp1^a
Immunology: RT1-A¹, RT2^a

Coat Color Loci:

a, Tyr^c

Color:

Albino

Species:

Rat

Animal Diet:

NIH #31M Rodent Diet

Growth Chart

n= 100 per sex at MPF health standard from US production colonies. Data collected 2012-14.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves. Growth charts are provided only as a guide.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.

Phenotypic Data

Average litter size: 6

Sexual Maturity: females at approximately 8 - 10 weeks of age males at approximately 10 - 12 weeks of age
Pregnancy: approximately 21 - 23 days
Weaning: approximately 28 days of age
Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.