Goto Kakizaki Inbred Rat Model
Alert: This model will no longer be available for sale by weight effective November 1, 2019.

  • Model #
  • Genotype
  • Nomenclature
  • GK-F
    GK/MolTac
  • GK-M
    GK/MolTac
  • A non-obese model of Non-Insulin Dependent Diabetes Mellitus (NIDDM), type II diabetes.
  • It exhibits similar metabolic, hormonal, and vascular disorders to the human diabetes disease.
  • Males develop type II diabetes at approximately 14 - 16 weeks of age.
  • Characteristics include fasting hyperglycemia, impaired secretion of insulin in response to glucose both in vivo and in isolated pancreatic cells, hepatic and peripheral insulin resistance and polyuria
  • Late complications such as retinopathy, microangiopathy, neuropathy, and nephropathy have been described in literature
  • Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.
  • The GK colony was derived from inbred stock and is bred randomly in a closed colony.

Origin:

The Goto-Kakizaki inbred model was developed by Tohoku University in 1975. Aarhus University Hospital in Denmark received stock in 1994. M&B A/S (now Taconic Europe) received stock from Aarhus in 1997. The rats were derived by embryo transfer in 2005 at Taconic US.

Genetics:

  • Strain Pro?le: Aco1b, Alpa, Amy2a, Anpepa, Es1a, Es2a, Es3a, Es4a, Es4b, Es6a, Es7b, Es9a, Esda, Es14b, Es15a, Es18a, Fh1b, Hao1a, Hbba, Pepcb , Pgd1b, Svp1a
  • Immunology: RT1-A1, RT2a

Coat Color Loci:

a, Tyrc

Color:

Albino

Species:

Rat


Taconic cannot routinely accept orders by weight for this model due to colony size. Please inquire for options if weight is critical for your experiment.

n= 100 per sex at MPF health standard from US production colonies. Data collected 2012-14.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves. Growth charts are provided only as a guide.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.
Average litter size: 6
  • Sexual Maturity: females at approximately 8 - 10 weeks of age males at approximately 10 - 12 weeks of age
  • Pregnancy: approximately 21 - 23 days
  • Weaning: approximately 28 days of age
  • Phenotypes, particularly blood glucose, are diet dependent and we recommend feeding NIH31-M.