NOG-EXL (hGM-CSF/hIL-3 NOG) Publications

NOG-EXL (hGM-CSF/hIL-3 NOG) Model Page

Filter publications by application: All Diabetes (Type 1) Gene/Cell therapy Hematopoietic Stem Cell Engraftment Humanized Hypersensitivities Immuno-Oncology Immunology Immunotherapy Induced Pluripotent Stem Cells (iPSCs) Infectious Disease Inflammation Leukemia Melanoma NK Oncology Patient Derived Xenograft (PDX) Stem Cells/Regenerative Medicine/Tissue Engineering T And/Or B Cell Function Therapeutic Efficacy Evaluation
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Shu L, et al.
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Shu L, Li X, Liu Z, Li K, Shi A, Tang Y, Zhao L, Huang L, Zhang Z, Zhang D, Huang S, Lian S, Sheng G, Yan Z, Zhang Z, Xu Y		 (2023) Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness and progression by targeting HPGD and increasing PGE2 generation. Hepatology
Jimbo K, et al.
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Jimbo K, Hattori A, Koide S, Ito T, Sasaki K, Iwai K, Nannya Y, Iwama A, Tojo A, Konuma T		 (2023) Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia. Leukemia 37(1):122-133
Gutierrez-Barbosa H, et al.
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Gutierrez-Barbosa H, Medina-Moreno S, Perdomo-Celis F, Davis H, Coronel-Ruiz C, Zapata JC, Chua JV		 (2023) A Comparison of Lymphoid and Myeloid Cells Derived from Human Hematopoietic Stem Cells Xenografted into NOD-Derived Mouse Strains. Microorganisms 11(6)
Manni S, et al.
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Manni S, Del Bufalo F, Merli P, Silvestris DA, Guercio M, Caruso S, Reddel S, Iaffaldano L, Pezzella M, Di Cecca S, Sinibaldi M, Ottaviani A, Quadraccia MC, Aurigemma M, Sarcinelli A, Ciccone R, Abbaszadeh Z, Ceccarelli M, De Vito R, Lodi MC, Cefalo MG, Mastronuzzi A, De Angelis B, Locatelli F, Quintarelli C		 (2023) Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies. Nat Commun 14(1):3423
T And/Or B Cell Function, Oncology, Immunotherapy, Immuno-Oncology, Gene/Cell therapy
Caruso S, et al.
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Caruso S, De Angelis B, Del Bufalo F, Ciccone R, Donsante S, Volpe G, Manni S, Guercio M, Pezzella M, Iaffaldano L, Silvestris DA, Sinibaldi M, Di Cecca S, Pitisci A, Velardi E, Merli P, Algeri M, Lodi M, Paganelli V, Serafini M, Riminucci M, Locatelli F, Quintarelli C		 (2022) Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia. J Hematol Oncol 15(1):163
NK, Immunotherapy, Leukemia, Immuno-Oncology, Gene/Cell therapy
Yang J, et al.
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Yang J, Deresa I, Ho WH, Long H, Maslyar D, Rosenthal A, Liang SC, Pincetic A		 (2022) AL008 Enhances Myeloid Antitumor Function by Inhibiting SIRP? Signaling and Activating Fc Receptors. J Immunol
Ghoneim MA, et al.
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Ghoneim MA, Gabr MM, Refaie AF, El-Halawani SM, Al-Issawi MM, Elbassiouny BL, Kader MAAE, Ismail AM, Zidan MF, Karras MS, Magar RW, Khater SM, Ashamallah SA, Zakaria MM, Kloc M		 (2022) Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice. Stem Cell Res Ther 13(1):350
Diabetes (Type 1), Stem Cells/Regenerative Medicine/Tissue Engineering, Induced Pluripotent Stem Cells (iPSCs)
Dal Bello R, et al.
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Dal Bello R, Pasanisi J, Joudinaud R, Duchmann M, Pardieu B, Ayaka P, Di Feo G, Sodaro G, Chauvel C, Kim R, Vasseur L, Chat L, Ling F, Pacchiardi K, Vaganay C, Berrou J, Benaksas C, Boissel N, Braun T, Preudhomme C, Dombret H, Raffoux E, Fenouille N, Clappier E, Ad�s L, Puissant A, Itzykson R		 (2022) A multiparametric niche-like drug screening platform in acute myeloid leukemia. Blood Cancer J 12(6):95
Oncology, Leukemia, Patient Derived Xenograft (PDX)
Albert DH, et al.
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Albert DH, Goodwin NC, Davies AM, Rowe J, Feuer G, Boyiadzis M, Dorritie KA, Mancini M, Gandour-Edwards R, Jonas BA, Borthakur G, Aldoss I, Rizzieri DA, Odenike O, Prebet T, Singh S, Popovic R, Shen YU, McDaniel KF, Kati WM, Modi DA, Motwani M, Wolff JE, Frost DJ		 (2022) Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML. In Vivo 36(4):1615-1627
Oncology, Leukemia, Patient Derived Xenograft (PDX)
Bartels L, et al.
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Bartels L, de Jong G, Gillissen MA, Yasuda E, Kattler V, Bru C, Fatmawati C, van Hal-van Veen SE, Cercel MG, Moiset G, Bakker AQ, van Helden PM, Villaudy J, Hazenberg MD, Spits H, Wagner K		 (2019) A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia. Cancer Res 79(13):3372-3382
Oncology, Leukemia, Therapeutic Efficacy Evaluation, Immuno-Oncology
Roux B, et al.
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Roux B, Vaganay C, Vargas JD, Alexe G, Benaksas C, Pardieu B, Fenouille N, Ellegast JM, Malolepsza E, Ling F, Sodaro G, Ross L, Pikman Y, Conway AS, Tang Y, Wu T, Anderson DJ, Le Moigne R, Zhou HJ, Luciano F, Hartigan CR, Galinsky I, DeAngelo DJ, Stone RM, Auberger P, Schenone M, Carr SA, Guirouilh-Barbat J, Lopez B, Khaled M, Lage K, Hermine O, Hemann MT, Puissant A, Stegmaier K, Benajiba L		 (2021) Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor. Sci Transl Med 13(587)
Pardieu B, et al.
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Pardieu B, Pasanisi J, Ling F, Dal Bello R, Penneroux J, Su A, Joudinaud R, Chat L, Wu HC, Duchmann M, Sodaro G, Chauvel C, Castelli FA, Vasseur L, Pacchiardi K, Belloucif Y, Laiguillon MC, Meduri E, Vaganay C, Alexe G, Berrou J, Benaksas C, Forget A, Braun T, Gardin C, Raffoux E, Clappier E, Ad�s L, de Th� H, Fenaille F, Huntly BJ, Stegmaier K, Dombret H, Fenouille N, Lobry C, Puissant A, Itzykson R		 (2022) Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia. Leukemia 36(6):1585-1595
Lin KH, et al.
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Lin KH, Rutter JC, Xie A, Pardieu B, Winn ET, Bello RD, Forget A, Itzykson R, Ahn YR, Dai Z, Sobhan RT, Anderson GR, Singleton KR, Decker AE, Winter PS, Locasale JW, Crawford L, Puissant A, Wood KC		 (2020) Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Nat Genet 52(4):408-417
Lin KH, et al.
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Lin KH, Rutter JC, Xie A, Killarney ST, Vaganay C, Benaksas C, Ling F, Sodaro G, Meslin PA, Bassil CF, Fenouille N, Hoj J, Washart R, Ang HX, Cerda-Smith C, Chaintreuil P, Jacquel A, Auberger P, Forget A, Itzykson R, Lu M, Lin J, Pierobon M, Sheng Z, Li X, Chilkoti A, Owzar K, Rizzieri DA, Pardee TS, Benajiba L, Petricoin E, Puissant A, Wood KC		 (2022) P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia. Nat Cancer
Little CJ, et al.
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Little CJ, Haynes WJ, Huang L, Daffada CM, Wolfe KB, Perrin E, Simpson JA, Kropp Schmidt JA, Hinkle HM, Keding LT, Behrens RT, Evans DT, Kaufman DB, Thomson JA, Golos TG, Brown ME		 (2022) Robust engraftment of fetal nonhuman primate CD34-positive cells in immune-deficient mice. J Leukoc Biol
Immunology, Hematopoietic Stem Cell Engraftment, Infectious Disease
Kumar S, et al.
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Kumar S, Ghosh S, Sharma G, Wang Z, Kehry MR, Marino MH, Neben TY, Lu S, Luo S, Roberts S, Ramaswamy S, Danaee H, Jenkins D		 (2021) Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models. MAbs 13(1):1954136
Immunology
Vendramin R, et al.
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Vendramin R, Katopodi V, Cinque S, Konnova A, Knezevic Z, Adnane S, Verheyden Y, Karras P, Demesmaeker E, Bosisio FM, Kucera L, Rozman J, Gladwyn-Ng I, Rizzotto L, Dassi E, Millevoi S, Bechter O, Marine JC, Leucci E		 (2021) Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma. J Exp Med 218(9)
Oncology, Melanoma, Patient Derived Xenograft (PDX), Therapeutic Efficacy Evaluation
Tran NT, et al.
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Tran NT, Graf R, Wulf-Goldenberg A, Stecklum M, Strau� G, K�hn R, Kocks C, Rajewsky K, Chu VT		 (2020) CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia. Mol Ther 28(12):2621-2634
Dai G, et al.
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Dai G, Wanek A, Eddens T, Volden P, Kolls JK		 (2021) Toward a humanized mouse model of Pneumocystis pneumonia. JCI Insight 6(2)
Infectious Disease
Ito R, et al.
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Ito R, Katano I, Otsuka I, Takahashi T, Suemizu H, Ito M, Simons PJ		 (2020) Bovine ?-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice. Int Immunol
Immunology
Maser IP, et al.
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Maser IP, Hoves S, Bayer C, Heidkamp G, Nimmerjahn F, Eckmann J, Ries CH		 (2020) The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models. Front Immunol 11:2082
Verma B, et al.
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Verma B, Wesa A		 (2020) Establishment of Humanized Mice from Peripheral Blood Mononuclear Cells or Cord Blood CD34+ Hematopoietic Stem Cells for Immune-Oncology Studies Evaluating New Therapeutic Agents. Curr Protoc Pharmacol 89(1):e77
T And/Or B Cell Function, Humanized
Cidado J, et al.
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Cidado J, Boiko S, Proia T, Ferguson D, Criscione SW, San Martin M, Pop-Damkov P, Su N, Roamio Franklin VN, Sekhar Reddy Chilamakuri C, D'Santos CS, Shao W, Saeh JC, Koch R, Weinstock DM, Zinda M, Fawell SE, Drew L		 (2019) AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells. Clin. Cancer Res.
Ghosh S, et al.
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Ghosh S, Sharma G, Travers J, Kumar S, Choi J, Jun HT, Kehry M, Ramaswamy S, Jenkins D		 (2019) TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade and . Mol. Cancer Ther. 18(3):632-641
Wang Z, et al.
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Wang Z, Sun K, Xiao Y, Feng B, Mikule K, Ma X, Feng N, Vellano CP, Federico L, Marszalek JR, Mills GB, Hanke J, Ramaswamy S, Wang J		 (2019) Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models. Sci Rep 9(1):1853
Weaver JL, et al.
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Weaver JL, Zadrozny LM, Gabrielson K, Semple KM, Shea KI, Howard KE		 (2019) BLT-immune humanized mice as a model for nivolumab induced immune-mediated adverse events: Comparison of the NOG and NOG-EXL strains. Toxicol. Sci.
Perdomo-Celis F, et al.
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Perdomo-Celis F, Medina-Moreno S, Davis H, Bryant J, Zapata JC		 (2019) HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice. Pathogens 8(1)
Ito R, et al.
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Ito R, Maruoka S, Soda K, Katano I, Kawai K, Yagoto M, Hanazawa A, Takahashi T, Ogura T, Goto M, Takahashi R, Toyoshima S, Okayama Y, Izuhara K, Gon Y, Hashimoto S, Ito M, Nunomura S		 (2018) A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis. JCI Insight 3(21)
Ito R, et al.
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Ito R, Nagai D, Igo N, Okuda Y, Sekine K, Ichimura E, Katano I, Mizushima T, Goto M, Ohnishi Y, Ito M, Okamoto K		 (2017) A novel in vivo model for predicting myelotoxicity of chemotherapeutic agents using IL-3/GM-CSF transgenic humanized mice. Toxicol. Lett. 281:152-157
Ito R, et al.
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Ito R, Takahashi T, Katano I, Kawai K, Kamisako T, Ogura T, Ida-Tanaka M, Suemizu H, Nunomura S, Ra C, Mori A, Aiso S, Ito M		 (2013) Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice. J. Immunol. 191(6):2890-9
Immunology, Inflammation, Hypersensitivities, Humanized
Fukuchi Y, et al.
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Fukuchi Y, Miyakawa Y, Kobayashi K, Kuramochi T, Shimamura K, Tamaoki N, Nomura T, Ueyama Y, Ito M		 (1998) Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice. Leuk. Res. 22(9):837-43
Oncology, Leukemia, Humanized
Mamoru Ito, et al.
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Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Sugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata		 (2002) NOD/SCID/? nullc mouse: an excellent recipient mouse model for engraftment of human cells Blood 2002 100:3175-3182
Humanized
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