Car Knockout Mouse Publications

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Shmarakov IO, et al.
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Shmarakov IO, Lee YJ, Jiang H, Blaner WS
(2019) Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis. Toxicol Appl Pharmacol 381:114731
LaRocca JL, et al.
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LaRocca JL, Rasoulpour RJ, Gollapudi BB, Eisenbrandt DL, Murphy LA, LeBaron MJ
(2017) Integration of novel approaches demonstrates simultaneous metabolic inactivation and CAR-mediated hepatocarcinogenesis of a nitrification inhibitor. Toxicol Rep 4:586-597
Hudson GM, et al.
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Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA
(2017) Constitutive androstane receptor regulates the intestinal mucosal response to injury. Br J Pharmacol 174(12):1857-1871
de Vries EM, et al.
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de Vries EM, Lammers LA, Achterbergh R, Kl�mpen HJ, Mathot RA, Boelen A, Romijn JA
(2016) Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR. PLoS One 11(7):e0159552
Tschuor C, et al.
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Tschuor C, Kachaylo E, Limani P, Raptis DA, Linecker M, Tian Y, Herrmann U, Grabliauskaite K, Weber A, Columbano A, Graf R, Humar B, Clavien PA
(2016) Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss. J Hepatol 65(1):66-74
Wang Z, et al.
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Wang Z, Neal BH, Lamb JC, Klaunig JE
(2015) Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. Toxicol Sci 147(2):549-61
Rondini EA, et al.
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Rondini EA, Duniec-Dmuchowski Z, Kocarek TA
(2016) Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes. Drug Metab Dispos 44(4):595-604
McMahon M, et al.
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McMahon M, Ding S, Jimenez LA, Terranova R, Gerard MA, Vitobello A, Moggs J, Henderson CJ, Wolf CR
(2019) Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes. Mol Pharmacol 95(1):97-105
Wahlang B, et al.
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Wahlang B, Alexander NC, Li X, Rouchka EC, Kirpich IA, Cave MC
(2021) Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. Toxicol Rep 8:536-547
Wang Z, et al.
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Wang Z, Wu Q, Li X, Klaunig JE
(2020) Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse. Arch Toxicol 94(8):2873-2884
Wang Z, et al.
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Wang Z, Li X, Wu Q, Lamb JC, Klaunig JE
(2017) Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor. J Appl Toxicol 37(8):967-975
Scheer N, et al.
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Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR
(2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J. Clin. Invest. 118(9):3228-39

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