Author(s) |
(Date) |
Paper Title |
Citation |
Model Type |
Applications |
Full Text |
| Margeta MA, et al. Mouse over for full list |
(2022) | Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. | Immunity | |||
| Pontifex MG, et al. Mouse over for full list |
(2022) | DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the APOE4 Genotype in Rodents. | Nutrients 14(9) | Alzheimer's | ||
| Pontifex MG, et al. Mouse over for full list |
(2021) | APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE-TR mice. | FASEB J 35(5):e21583 | Behavior, Metabolism, Alzheimer's | ||
| Miranda AM, et al. Mouse over for full list |
(2022) | Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice. | Transl Psychiatry 12(1):129 | |||
| Xiong M, et al. Mouse over for full list |
(2021) | APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. | Sci Transl Med 13(581) | Gene replacement |
Cardiovascular, Neuroscience, Alzheimer's, Safety Assessment, Transgenic Model Generation | |
| Pohlkamp T, et al. Mouse over for full list |
(2021) | NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. | Elife 10 | Alzheimer's | ||
| Fang W, et al. Mouse over for full list |
(2021) | APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline. | Transl Psychiatry 11(1):507 | Behavior, Metabolism | ||
| Toro CA, et al. Mouse over for full list |
(2021) | The Human ApoE4 Variant Reduces Functional Recovery and Neuronal Sprouting After Incomplete Spinal Cord Injury in Male Mice. | Front Cell Neurosci 15:626192 | |||
| Schmitt J, et al. Mouse over for full list |
(2021) | Flexibility as a marker of early cognitive decline in humanized apolipoprotein E ε4 (ApoE4) mice. | Neurobiol Aging 102:129-138 | |||
| Shang Y, et al. Mouse over for full list |
(2020) | Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. | PLoS ONE 15(1):e0225392 | Alzheimer's | ||
| Caberlotto L, et al. Mouse over for full list |
(2019) | Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases. | Sci Rep 9(1):3965 | Alzheimer's, Diabetes (Type 2) | ||
| Wu L, et al. Mouse over for full list |
(2018) | Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. | J. Neurosci. | |||
| Hunter JM, et al. Mouse over for full list |
(2012) | Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. | Brain Res. 1467:120-32 | Alzheimer's | ||
| Yong SM, et al. Mouse over for full list |
(2014) | Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. | Sci Rep 4:6580 | Alzheimer's | ||
| Slim KE, et al. Mouse over for full list |
(2017) | The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice. | FASEB J. 31(3):989-997 | |||
| Ding JD, et al. Mouse over for full list |
(2011) | Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. | Proc. Natl. Acad. Sci. U.S.A. 108(28):E279-87 | Alzheimer's | ||
| Levy O, et al. Mouse over for full list |
(2015) | APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. | J. Neurosci. 35(40):13568-76 | |||
| Salomon-Zimri S, et al. Mouse over for full list |
(2016) | Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. | J. Alzheimers Dis. 53(4):1443-58 | Knock in, Humanization |
Cardiovascular, Metabolism, Neuroscience, Alzheimer's | |
| Janssen CI, et al. Mouse over for full list |
(2016) | The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice. | PLoS ONE 11(5):e0155307 | Knock out, Knock in, Humanization |
Neuroscience, Alzheimer's | |
| Salomon-Zimri S, et al. Mouse over for full list |
(2015) | Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. | Alzheimers Dement (Amst) 1(2):127-35 | Knock in |
Behavior, Neuroscience, Alzheimer's | |
| Segev Y, et al. Mouse over for full list |
(2016) | Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease. | Front Behav Neurosci 10:170 | Knock in |
Behavior, Metabolism, Neuroscience, Alzheimer's | |
| Li G, et al. Mouse over for full list |
(2009) | GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. | Cell Stem Cell 5(6):634-45 | Knock in |
Neuroscience, Alzheimer's | |
| Jenner AM, et al. Mouse over for full list |
(2010) | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | Neuroscience 169(1):109-15 | Knock in |
Metabolism, Neuroscience, Alzheimer's | |
| Andrews-Zwilling Y, et al. Mouse over for full list |
(2010) | Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. | J. Neurosci. 30(41):13707-17 | Knock in |
Neuroscience, Alzheimer's | |
| Leung L, et al. Mouse over for full list |
(2012) | Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. | PLoS ONE 7(12):e53569 | Knock in |
Neuroscience, Alzheimer's | |
| Ong QR, et al. Mouse over for full list |
(2014) | Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver. | FEBS Open Bio 4:260-5 | Knock in |
Metabolism, Neuroscience, Alzheimer's | |
| Tong LM, et al. Mouse over for full list |
(2016) | Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. | J. Neurosci. 36(7):2316-22 | Knock in |
Neuroscience, Alzheimer's | |
| Alata W, et al. Mouse over for full list |
(2015) | Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. | J. Cereb. Blood Flow Metab. 35(1):86-94 | Knock in |
Neuroscience, Alzheimer's | |
| Ramaswamy G, et al. Mouse over for full list |
(2005) | Effect of domain interaction on apolipoprotein E levels in mouse brain. | J. Neurosci. 25(46):10658-63 | |||
| Pfankuch T, et al. Mouse over for full list |
(2005) | Role of circulating androgen levels in effects of apoE4 on cognitive function. | Brain Res. 1053(1-2):88-96 | Alzheimer's | ||
| Huang Y Mouse over for full list |
(2006) | Apolipoprotein E and Alzheimer disease. | Neurology 66(2 Suppl 1):S79-85 | Alzheimer's | ||
| Malek G, et al. Mouse over for full list |
(2005) | Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. | Proc. Natl. Acad. Sci. U.S.A. 102(33):11900-5 | |||
| Knouff C, et al. Mouse over for full list |
(1999) | Apo E structure determines VLDL clearance and atherosclerosis risk in mice. | J. Clin. Invest. 103(11):1579-86 |
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