APOE4 Publications

APOE4 Model Page

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Filter publications by model type: All Humanization Knock in Knock out

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Slim KE, et al.
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Slim KE, Vauzour D, Tejera N, Voshol PJ, Cassidy A, Minihane AM
(2017) The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice. FASEB J. 31(3):989-997
Levy O, et al.
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Levy O, Lavalette S, Hu SJ, Housset M, Raoul W, Eandi C, Sahel JA, Sullivan PM, Guillonneau X, Sennlaub F
(2015) APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. J. Neurosci. 35(40):13568-76
Salomon-Zimri S, et al.
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Salomon-Zimri S, Glat MJ, Barhum Y, Luz I, Boehm-Cagan A, Liraz O, Ben-Zur T, Offen D, Michaelson DM
(2016) Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. J. Alzheimers Dis. 53(4):1443-58
Knock in, Humanization
Cardiovascular, Metabolism, Neuroscience, Alzheimer's
Janssen CI, et al.
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Janssen CI, Jansen D, Mutsaers MP, Dederen PJ, Geenen B, Mulder MT, Kiliaan AJ
(2016) The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice. PLoS ONE 11(5):e0155307
Knock out, Knock in, Humanization
Neuroscience, Alzheimer's
Salomon-Zimri S, et al.
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Salomon-Zimri S, Liraz O, Michaelson DM
(2015) Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. Alzheimers Dement (Amst) 1(2):127-35
Knock in
Behavior, Neuroscience, Alzheimer's
Segev Y, et al.
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Segev Y, Livne A, Mints M, Rosenblum K
(2016) Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease. Front Behav Neurosci 10:170
Knock in
Behavior, Metabolism, Neuroscience, Alzheimer's
Li G, et al.
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Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y
(2009) GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell 5(6):634-45
Knock in
Neuroscience, Alzheimer's
Jenner AM, et al.
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Jenner AM, Lim WL, Ng MP, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN
(2010) The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience 169(1):109-15
Knock in
Metabolism, Neuroscience, Alzheimer's
Andrews-Zwilling Y, et al.
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Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y
(2010) Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J. Neurosci. 30(41):13707-17
Knock in
Neuroscience, Alzheimer's
Leung L, et al.
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Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y
(2012) Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS ONE 7(12):e53569
Knock in
Neuroscience, Alzheimer's
Ong QR, et al.
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Ong QR, Chan ES, Lim ML, Wong BS
(2014) Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver. FEBS Open Bio 4:260-5
Knock in
Metabolism, Neuroscience, Alzheimer's
Tong LM, et al.
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Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y
(2016) Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. J. Neurosci. 36(7):2316-22
Knock in
Neuroscience, Alzheimer's
Alata W, et al.
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Alata W, Ye Y, St-Amour I, Vandal M, Calon F
(2015) Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J. Cereb. Blood Flow Metab. 35(1):86-94
Knock in
Neuroscience, Alzheimer's
Ramaswamy G, et al.
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Ramaswamy G, Xu Q, Huang Y, Weisgraber KH
(2005) Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci. 25(46):10658-63
Raber J, et al.
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Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L
(1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. U.S.A. 95(18):10914-9
Pfankuch T, et al.
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Pfankuch T, Rizk A, Olsen R, Poage C, Raber J
(2005) Role of circulating androgen levels in effects of apoE4 on cognitive function. Brain Res. 1053(1-2):88-96
Alzheimer's
Huang Y
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Huang Y
(2006) Apolipoprotein E and Alzheimer disease. Neurology 66(2 Suppl 1):S79-85
Alzheimer's
Malek G, et al.
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Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C
(2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc. Natl. Acad. Sci. U.S.A. 102(33):11900-5
Knouff C, et al.
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Knouff C, Hinsdale ME, Mezdour H, Altenburg MK, Watanabe M, Quarfordt SH, Sullivan PM, Maeda N
(1999) Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J. Clin. Invest. 103(11):1579-86