APOE4 Publications

APOE4 Model Page

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Toro CA, et al.
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Toro CA, Hansen J, Siddiq MM, Johnson K, Zhao W, Azulai D, Das DK, Bauman W, Sebra R, Cai D, Iyengar R, Cardozo CP		 (2021) The Human ApoE4 Variant Reduces Functional Recovery and Neuronal Sprouting After Incomplete Spinal Cord Injury in Male Mice. Front Cell Neurosci 15:626192
Schmitt J, et al.
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Schmitt J, Paradis AL, Boucher M, Andrieu L, Barnéoud P, Rondi-Reig L		 (2021) Flexibility as a marker of early cognitive decline in humanized apolipoprotein E ε4 (ApoE4) mice. Neurobiol Aging 102:129-138
Shang Y, et al.
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Shang Y, Mishra A, Wang T, Wang Y, Desai M, Chen S, Mao Z, Do L, Bernstein AS, Trouard TP, Brinton RD		 (2020) Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. PLoS ONE 15(1):e0225392
Alzheimer's
Caberlotto L, et al.
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Caberlotto L, Nguyen TP, Lauria M, Priami C, Rimondini R, Maioli S, Cedazo-Minguez A, Sita G, Morroni F, Corsi M, Carboni L		 (2019) Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases. Sci Rep 9(1):3965
Alzheimer's, Diabetes (Type 2)
Wu L, et al.
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Wu L, Zhang X, Zhao L		 (2018) Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J. Neurosci.
Hunter JM, et al.
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Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM		 (2012) Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Res. 1467:120-32
Alzheimer's
Yong SM, et al.
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Yong SM, Lim ML, Low CM, Wong BS		 (2014) Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. Sci Rep 4:6580
Alzheimer's
Slim KE, et al.
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Slim KE, Vauzour D, Tejera N, Voshol PJ, Cassidy A, Minihane AM		 (2017) The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice. FASEB J. 31(3):989-997
Levy O, et al.
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Levy O, Lavalette S, Hu SJ, Housset M, Raoul W, Eandi C, Sahel JA, Sullivan PM, Guillonneau X, Sennlaub F		 (2015) APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. J. Neurosci. 35(40):13568-76
Salomon-Zimri S, et al.
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Salomon-Zimri S, Glat MJ, Barhum Y, Luz I, Boehm-Cagan A, Liraz O, Ben-Zur T, Offen D, Michaelson DM		 (2016) Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. J. Alzheimers Dis. 53(4):1443-58
Knock in, Humanization
 Cardiovascular, Metabolism, Neuroscience, Alzheimer's
Janssen CI, et al.
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Janssen CI, Jansen D, Mutsaers MP, Dederen PJ, Geenen B, Mulder MT, Kiliaan AJ		 (2016) The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice. PLoS ONE 11(5):e0155307
Knock out, Knock in, Humanization
 Neuroscience, Alzheimer's
Salomon-Zimri S, et al.
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Salomon-Zimri S, Liraz O, Michaelson DM		 (2015) Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. Alzheimers Dement (Amst) 1(2):127-35
Knock in
 Behavior, Neuroscience, Alzheimer's
Segev Y, et al.
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Segev Y, Livne A, Mints M, Rosenblum K		 (2016) Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease. Front Behav Neurosci 10:170
Knock in
 Behavior, Metabolism, Neuroscience, Alzheimer's
Li G, et al.
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Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y		 (2009) GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell 5(6):634-45
Knock in
 Neuroscience, Alzheimer's
Jenner AM, et al.
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Jenner AM, Lim WL, Ng MP, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN		 (2010) The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience 169(1):109-15
Knock in
 Metabolism, Neuroscience, Alzheimer's
Andrews-Zwilling Y, et al.
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Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y		 (2010) Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J. Neurosci. 30(41):13707-17
Knock in
 Neuroscience, Alzheimer's
Leung L, et al.
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Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y		 (2012) Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. PLoS ONE 7(12):e53569
Knock in
 Neuroscience, Alzheimer's
Ong QR, et al.
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Ong QR, Chan ES, Lim ML, Wong BS		 (2014) Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver. FEBS Open Bio 4:260-5
Knock in
 Metabolism, Neuroscience, Alzheimer's
Tong LM, et al.
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Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y		 (2016) Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. J. Neurosci. 36(7):2316-22
Knock in
 Neuroscience, Alzheimer's
Alata W, et al.
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Alata W, Ye Y, St-Amour I, Vandal M, Calon F		 (2015) Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J. Cereb. Blood Flow Metab. 35(1):86-94
Knock in
 Neuroscience, Alzheimer's
Ramaswamy G, et al.
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Ramaswamy G, Xu Q, Huang Y, Weisgraber KH		 (2005) Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci. 25(46):10658-63
Raber J, et al.
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Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L		 (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc. Natl. Acad. Sci. U.S.A. 95(18):10914-9
Pfankuch T, et al.
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Pfankuch T, Rizk A, Olsen R, Poage C, Raber J		 (2005) Role of circulating androgen levels in effects of apoE4 on cognitive function. Brain Res. 1053(1-2):88-96
Alzheimer's
Huang Y
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Huang Y		 (2006) Apolipoprotein E and Alzheimer disease. Neurology 66(2 Suppl 1):S79-85
Alzheimer's
Malek G, et al.
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Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C		 (2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc. Natl. Acad. Sci. U.S.A. 102(33):11900-5
Knouff C, et al.
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Knouff C, Hinsdale ME, Mezdour H, Altenburg MK, Watanabe M, Quarfordt SH, Sullivan PM, Maeda N		 (1999) Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J. Clin. Invest. 103(11):1579-86
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