Author(s) |
(Date) |
Paper Title |
Citation |
Model Type |
Applications |
Full Text |
| Hunter JM, et al. Mouse over for full list |
(2012) | Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. | Brain Res. 1467:120-32 | Alzheimer's | ||
| Yong SM, et al. Mouse over for full list |
(2014) | Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice. | Sci Rep 4:6580 | Alzheimer's | ||
| Slim KE, et al. Mouse over for full list |
(2017) | The effect of dietary fish oil on weight gain and insulin sensitivity is dependent on APOE genotype in humanized targeted replacement mice. | FASEB J. 31(3):989-997 | |||
| Levy O, et al. Mouse over for full list |
(2015) | APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. | J. Neurosci. 35(40):13568-76 | |||
| Salomon-Zimri S, et al. Mouse over for full list |
(2016) | Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. | J. Alzheimers Dis. 53(4):1443-58 | Knock in, Humanization |
Cardiovascular, Metabolism, Neuroscience, Alzheimer's | |
| Janssen CI, et al. Mouse over for full list |
(2016) | The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice. | PLoS ONE 11(5):e0155307 | Knock out, Knock in, Humanization |
Neuroscience, Alzheimer's | |
| Salomon-Zimri S, et al. Mouse over for full list |
(2015) | Behavioral testing affects the phenotypic expression of APOE ε3 and APOE ε4 in targeted replacement mice and reduces the differences between them. | Alzheimers Dement (Amst) 1(2):127-35 | Knock in |
Behavior, Neuroscience, Alzheimer's | |
| Segev Y, et al. Mouse over for full list |
(2016) | Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease. | Front Behav Neurosci 10:170 | Knock in |
Behavior, Metabolism, Neuroscience, Alzheimer's | |
| Li G, et al. Mouse over for full list |
(2009) | GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. | Cell Stem Cell 5(6):634-45 | Knock in |
Neuroscience, Alzheimer's | |
| Jenner AM, et al. Mouse over for full list |
(2010) | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | Neuroscience 169(1):109-15 | Knock in |
Metabolism, Neuroscience, Alzheimer's | |
| Andrews-Zwilling Y, et al. Mouse over for full list |
(2010) | Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. | J. Neurosci. 30(41):13707-17 | Knock in |
Neuroscience, Alzheimer's | |
| Leung L, et al. Mouse over for full list |
(2012) | Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice. | PLoS ONE 7(12):e53569 | Knock in |
Neuroscience, Alzheimer's | |
| Ong QR, et al. Mouse over for full list |
(2014) | Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver. | FEBS Open Bio 4:260-5 | Knock in |
Metabolism, Neuroscience, Alzheimer's | |
| Tong LM, et al. Mouse over for full list |
(2016) | Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice. | J. Neurosci. 36(7):2316-22 | Knock in |
Neuroscience, Alzheimer's | |
| Alata W, et al. Mouse over for full list |
(2015) | Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. | J. Cereb. Blood Flow Metab. 35(1):86-94 | Knock in |
Neuroscience, Alzheimer's | |
| Ramaswamy G, et al. Mouse over for full list |
(2005) | Effect of domain interaction on apolipoprotein E levels in mouse brain. | J. Neurosci. 25(46):10658-63 | |||
| Raber J, et al. Mouse over for full list |
(1998) | Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. | Proc. Natl. Acad. Sci. U.S.A. 95(18):10914-9 | |||
| Pfankuch T, et al. Mouse over for full list |
(2005) | Role of circulating androgen levels in effects of apoE4 on cognitive function. | Brain Res. 1053(1-2):88-96 | Alzheimer's | ||
| Huang Y Mouse over for full list |
(2006) | Apolipoprotein E and Alzheimer disease. | Neurology 66(2 Suppl 1):S79-85 | Alzheimer's | ||
| Malek G, et al. Mouse over for full list |
(2005) | Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. | Proc. Natl. Acad. Sci. U.S.A. 102(33):11900-5 | |||
| Knouff C, et al. Mouse over for full list |
(1999) | Apo E structure determines VLDL clearance and atherosclerosis risk in mice. | J. Clin. Invest. 103(11):1579-86 |
