| Model No. | Nomenclature | Genotype |
|---|---|---|
| 13076 | B6;129P2-Trex1tm1Tld | Inquire for genotype |
Trex1 Knockout Mouse
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Overview
Nomenclature: B6;129P2-Trex1tm1Tld
- Constitutive knockout of the three prime repair exonuclease I gene (Trex1)
- Model of Aicardi-Goutieres syndrome
- Displays inflammatory myocarditis and autoimmune disease
- Homozygous knockouts have a reduced lifespan
Origin
The Trex1 Knockout Mouse was developed in the laboratories of Tomas Lindahl at the Clare Hall Laboratories, Imperial Cancer Research Fund (now Cancer Research UK). The model was created using a targeting vector that replaced amino acids 103-207 of the Trex1 open reading frame with a neo cassette in GK129 ES cells derived from the 129P2 strain. Targeted ES cells were injected into C57BL/6J blastocysts. Taconic received frozen embryos from CRT in 2013.
Source: Cancer Research Technology
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication:
Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE. (2004) Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol. 24(15):6719-27.
Applications & Therapeutic Areas
- Immunology
- Inflammation
Transit, Housing & Welfare
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- Licensing
- Pricing - USD
- Pricing - EUR
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Trex1 Knockout Mouse
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
13076
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $14,700.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
13076
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €13.125,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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