Tbet Knockout (BALB/c)

Constitutive Knockout

Tbet Knockout (BALB/c)
EZcohort® Models
The easiest way to acquire and breed cryopreserved GEMs
This model is available for immediate cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • 3469
    C.129S6(B6)-Tbx21tm1Glm N10
  • Altered cytokine production and differentiation of T helper cells
  • Decreased NK cell function
  • Immune system hypersensitivity makes this an excellent model of asthma

Genetic Background:



The T-bet model was developed by Laurie H. Glimcher at Harvard University.  The model was creeated by targeting the Tbx21 gene in TC-1 ES cells and injecting the targeted cells into blastocysts.  Resultant chimeras were backcrossed to C57BL/6J for one generation and then backcrossed to BALB/cJ for nine generations..  Taconic received stock in 2004.  The line was backcrossed to BALB/cJBom for embryo transfer derivation (N10).  The colony was maintained through incrossing homozygous mice.





To purchase this EZcohort model, sign the terms of sale (choose from the list below) and email it directly to info@taconic.com with a purchase order for the purchase price:

This model is sold under terms which grant perpetual use rights.

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