sPLA2

Random Transgenic

sPLA<span style="text-transform: lowercase;">2</span> (Model 1005) Random Transgenic
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 1005
    B6.SJL-Tg(PLA2G2A)703 N?+16
  • Carries transgene for human Group II Phospholipase A2
  • Develops alopecia, epidermal hyperplasia and enlarged sebacious glands
  • Exhibits an increased susceptibility to LPS induced shock and atherosclerosis
  • Useful to identify and evaluate new drug candidates for treatement of human inflammatory conditions and atherosclerosis.

Genetic Background:

C57BL/6

Origin:

The sPLA2 mouse was developed by Xenogen Biosciences, now Taconic. The model was created by microinjecting the human sPLA2 gene into C57BL/6 x SJL zygotes. The line was subsequently backcrossed to C57BL/6NTac.


Color:

Black

Species:

Mouse

Initial Publication:

Grass, D.S., Felkner, R.H., Chiang, M., Wallace, R.E., Nevalainen, T.J., Bennett, C.F., Swanson, M.E. Expression of Human Group II PLA2 in Transgenic Mice Results in Epidermal Hyperplasia in the Absence of Inflammatory Infiltrate, J Clin Invest., Vol. 97, No. 10, May 1996, pp. 2233-2241.



To purchase this EZcohort model, sign the terms of sale (choose from the list below) and email it directly to info@taconic.com with a purchase order for the purchase price:

This model is sold under terms which grant perpetual use rights.