SJL Inbred Mouse Model

  • Model #
  • Genotype
  • Nomenclature
  • SJL-F
  • SJL-M
  • Exhibits a high incidence of reticulum cell sarcomas at approximately 12 months of age; resembles Hodgkin's Disease
  • Due to the SJL's resistance to diet-induced athlerosclerosis the model is also useful for Cardiovascular Research
  • Carries the H2s haplotype and the mutation for retinal degeneration, Pde6brd1
  • Males are exceptionally aggressive
  • The SJL is used as the male parent to produce the B6SJLF1 hybrid which is often used as the pronuclear cell donor in transgenic microinjection laboratories


The SJL inbred model was developed by Lambert et al of the Jackson Laboratory in 1955 from Swiss Webster outbred mice of three origins. The Cancer Research Center received stock from the Jackson Laboratory. The NIH Genetic Resource received stock from the Cancer Research Center. Taconic received stock at F9+ from the NIH Genetic Resource in 1999. The mice were derived by embryo transfer in 2000. The Taconic foundation colony was at F29 in 2005.


  • Strain Profile: Acy1s, Alada, Car2b, Cd8ab, Cd8b1b, Es1b, Es3c, Esdb, H6pd1b, Ggca, Gpi1a, Gus-sb, Hbbs, Idh1b, Ldr1a, Mod1a, Mpi1b, Pepcb, Pgm1b, Pnpa, Sod1a, Trfb
  • Immunology: H2s
  • Other: Ptprca
  • Retinal Degeneration: Pde6brd1

Coat Color Loci:

Tyrc, p





Orders by weight: Taconic cannot routinely accept orders by weight for this model due to colony size. Please inquire for options if weight is critical for your experiment.

n= 100 per sex at MPF, health standard from all global colonies. Data collected 2011-15.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.
Average litter size: 5

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