| Model No. | Nomenclature | Genotype |
|---|---|---|
| CBSCBG-F | C.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7 | sp/sp;sp/sp |
| CBSCBG-M | C.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7 | sp/sp;sp/sp |
scid-beige
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Overview
Nomenclature: C.B-Igh-1b/GbmsTac-Prkdcscid-Lystbg N7
- The mutations were backcrossed seven generations to the congenic C.B-17 background
- This double mutant model carries the scid mutation which causes a lack of both T and B lymphocytes due to a defect in V(D)J recombination
- It also carries the beige mutation which results in cytotoxic T cell and macrophage defects as well as selective impairment of NK cell functions. As a result, scid-beige mice are potentially an improved model for receipt of xenotransplants and for infectious disease studies
- It has also been observed that the C.B-17 scid-beige strain has a lower incidence of serum Ig relative to the C.B.-17 scid strain
Origin
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Cell and Tissue Humanized
- Immunology
- Inflammation
- Oncology & Immuno-Oncology
Transit, Housing & Welfare
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Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Average litter size: 6
- Pricing - USD
- Pricing - EUR
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Pricing - USD
Defined Flora (DF) Health Standard
CBSCBG Female
CBSCBG-F Genotype sp/sp;sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 6 | $197.00 |
| 7 to 10 | $222.00 |
CBSCBG Male
CBSCBG-M Genotype sp/sp;sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 6 | $197.00 |
| 7 to 10 | $222.00 |
Pricing - EUR
Defined Flora (DF) Health Standard
CBSCBG Female
CBSCBG-F Genotype sp/sp;sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 6 | €206,00 |
| 7 to 10 | €227,00 |
CBSCBG Male
CBSCBG-M Genotype sp/sp;sp/sp
| Age in Weeks | Quantity 1 - 999 |
| 3 to 6 | €206,00 |
| 7 to 10 | €227,00 |
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