Model No. | Nomenclature | Genotype |
---|---|---|
9179 | C57BL/6-Abcc2tm1(ABCC2)Arte | Inquire for genotype |
Nomenclature: C57BL/6-Abcc2tm1(ABCC2)Arte
Origin
The Humanized MRP2 Mouse was developed by Taconic in collaboration with CXR Biosciences. It was created through a targeted replacement of mouse Mrp2 Exon 2 with a cDNA construct containing human MRP2 Exons 2-32 in C57BL/6NTac-derived ES cells. This leads to the expression of a fusion protein of amino acids encoded by mouse Exons 1 and human Exons 2 to 32 driven by the mouse Mrp2 promoter, so that the potential mouse leader sequence encoded by Exon 1 is retained. Targeted ES cells were injected into BALB/cJBomTac blastocysts and the resultant chimeras were backcrossed to a Flpe deleter strain on C57BL/6J to eliminate the selection marker. Taconic received stock in 2009, and the line was embryo transfer derived. The colony was maintained by mating homozygotes.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Initial Publication:
Scheer N, Balimane P, Hayward MD, Buechel S, Kauselmann G, Wolf CR. Generation and Characterization of a Novel MRP2 Humanized Mouse Line. Drug Metab Dispos. 2012 Aug 23.
Additional Publications:
Wen X, Buckley B, McCandlish E, Goedken MJ, Syed S, Pelis R, Manautou JE, Aleksunes LM. Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice. Am J Pathol. 2014 184(5):1299-308.
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Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | $34,650.00 | $23,100.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Item | Commercial | Nonprofit |
---|---|---|
Cryopreserved Model | €26.250,00 | €19.425,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.