FcResolv™ huNOG

Humanized Immune System Mouse Model

FcResolv™ huNOG
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FcResolv™ huNOG mice are made to order, with a 20+ week lead time from order to delivery.

NOD Background

  • Model #
  • Genotype
  • Nomenclature
  • HSCCB-19164-F
    ko/ko;ko/ko;sp/sp;ko/ko
    NOD.Cg-Fcgr2btm1Ttk Fcer1gtm1Rav Prkdcscid Il2rgtm1Sug

A humanized immune system (HIS) mouse designed for more accurate assessment of antibody-based drugs.

  • The FcResolv™ huNOG is a HIS mouse made by engrafting hematopoietic stem cells (HSCs) in the FcResolv NOG strain.
  • Made to order, with typical lead time of 20 weeks from order to delivery. Minimum purchase required.
  • Human lymphocytes are present in peripheral blood, bone marrow and spleen.
  • All mice shipped meet a QC spec of ≥25% hCD45+ in peripheral blood as assessed at 12 weeks post-engraftment.
  • Long-term studies are possible in huNOG mice, with literature reports of stable engraftment and hematopoiesis for one year or more, and similar study windows are expected in FcResolv huNOG mice. However, not all human immune cell types are present, and some cell types may not be completely functional.
  • Humanized immune system mice require special housing and husbandry. We recommend reviewing the the comprehensive document Taconic's Humanized Immune System Models: Licensing, Care & Resources and the Video: Care of HIS mice for experimental success prior to ordering.

FcResolv NOG Characteristics

  • The FcResolv NOG is a super immunodeficient NOG mouse that has a further reduction in residual murine immune activity via ablation of mouse Fc gamma receptors (FcγRs) to improve accuracy of results.
  • Murine FcγRs can confound experiments in several ways, leading to false positive or negative results. Removing murine FcγRs provides improved accuracy for efficacy assessment of antibody-based therapies which include an Fc domain.
  • Lacks all murine Fcγ receptors, including the FcγRI, IIB, III and IV types, along with the high affinity FcεRI receptor. The low affinity FcεRII receptor remains present.
  • FcResolv NOG mice support higher average levels of human cells following engraftment with HSCs compared to the base NOG mouse; human cell frequencies may vary somewhat between the two humanized models.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

taconic biosciences insightRead the Related Taconic Biosciences Insight:

Availability:

  • Custom options such as HLA selection are available for an additional fee. Inquire regarding your specific needs.
  • Orders which specify a certain number of mice per donor are subject to availability and are not guaranteed, as orders may need to be adjusted at time of packing.

 FcResolv huNOG
Max n-value per donor35-40 mice
Minimum purchase20 mice per order; minimum 6-8 mice per donor.
TimelineEngrafted on-demand; 5-6 week order lead time, shipped ~14+ WPE
% mice guaranteed to meet QC standard100%
Cancellation policyMay not be canceled after order is booked
NOTE: Tattoo numbers may repeat between engraftment lots. Individual ID number is determined through examination of the tattoo PLUS the box and section location. Please contact Taconic prior to your first order for a review of unpacking instructions.

Color:

Albino

Species:

Mouse

Initial Publication:

  • Katano I, Ito R, Kawai K, Takahashi T. Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse. Front Immunol. 2020 Oct 7;11:532684.
  • Katano I, Hanazawa A, Otsuka I, Yamaguchi T, Mochizuki M, Kawai K, Ito R, Goto M, Kagawa T, Takahashi T. Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody. Sci Rep. 2021 Oct 26;11(1):21087.


Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions

For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.

Does your research require the use of neonates? Please contact us for more information on neonate access options.

The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
  • Japanese Patent No. 3,753,321
  • US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
    EP Patent No. 1,338,198
  • Japanese Trademark Reg. No. 4,823,423
  • US Trademark Reg. No. 3,118,040
  • EU Trademark Reg. No. 3,736,758

FcResolv huNOG mice have higher average engraftment compared to huNOG mice

FcResolv huNOG mice have higher average engraftment compared to huNOG mice
Figure 1: In a head-to-head comparison, FcResolv huNOG mice have equivalent or higher mean levels of human immune cells in peripheral blood compared to huNOG mice, across three different human donors.
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