| Model No. | Nomenclature | Genotype |
|---|---|---|
| 13787 | C57BL/6-Creg1tm1.1Mrl |
Creg1 - Model 13787 - KO
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Overview
Nomenclature: C57BL/6-Creg1tm1.1Mrl
- The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic's C57BL/6N Tac ES cell line.
- Creg1 exon 1 contains the translation initiation codon.
- Exon 1has been flanked by loxP sites including the FRT site flanked neomycin resistance gene cassette.
- The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
- The conditional KO line has been derived using C57BL/6NTac animals.
- The constitutive KO allele can be generated by Cre-mediated recombination.
- Deletion of exon 1 should result in loss of function of the Creg1 gene.
- The remaining recombination sites are located in non-conserved regions of the genome.
- Datamining and Design performed in 2009.
Availability
Cryopreserved at TaconicSource: Xenogen
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Transit, Housing & Welfare
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Creg1 - Model 13787 - KO
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
The GEM Collection Commercial and Academic Terms of Sale grant perpetual use rights.
| Item | Commercial | Nonprofit |
| Cryopreserved Model | $32,500 | $5,500 |
| Item | Commercial | Nonprofit |
| Cryopreserved Model | €29.500 | €5.005 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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