- The targeting vector has been generated using C57BL/6J DNA and transfected into Taconic's C57BL/6N Tac ES cell line.
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Creg1 exon 1 contains the translation initiation codon.
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Exon 1has been flanked by loxP sites including the FRT site flanked neomycin resistance gene cassette.
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The neomycin resistance gene cassette has been removed by transient transfection of Flp recombinase into targeted ES cell clones.
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The conditional KO line has been derived using C57BL/6NTac animals.
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The constitutive KO allele can be generated by Cre-mediated recombination.
- Deletion of exon 1 should result in loss of function of the Creg1 gene.
- The remaining recombination sites are located in non-conserved regions of the genome.
- Datamining and Design performed in 2009.
Gene Family:
Repressor Genetic Background:
C57BL/6 Gene Symbol:
Creg1 Gene Accession Number:
NM_011804 Allele Type:
KO Source:
Xenogen Availability:
Cryopreserved at Taconic Species:
Mouse Official Gene Name:
cellular repressor of E1A-stimulated genes 1