CRE-Luc GPCR Reporter Mouse, Line 64

Random Transgenic

Cryopreserved CRE-Luc GPCR Reporter Mouse, Line 64 - Taconic Biosciences
This line is cryopreserved and requires cryorecovery.

FVB Background

  • Model #
  • Genotype
  • Nomenclature
  • 11518-F
    tg/tg
    FVB/NTac-Tg(CRE/Tk-luc)64Hgp
  • 11518-M
    tg/tg
    FVB/NTac-Tg(CRE/Tk-luc)64Hgp
  • Expresses luciferase under the control of the cAMP response element (CRE)
  • GPCR signaling through the cAMP pathway can be detected from the target GPCR that is in a native cellular environment with a full compliment of associated receptors and membrane constituents
  • Luciferase is expressed primarily in the spleen and kidney in Line 64
  • Useful for screening in vivo, ex vivo, and in vitro using whole animals, tissues and primary cells
  • Learn more about the CRE-Luc GPCR Reporter Mouse Platform
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

FVB Background

Origin:

The CRE-Luc GPCR Reporter Mouse, Line 64 was developed by Sanofi. The model was created by microinjecting a transgene containing a 6x CRE promoter, the HSV TK minimal promoter, modified firefly luciferase cDNA from pGL4 and a human growth hormone polyA tail. This transgene was microinjected into FVB/NTac zygotes. The resultant mice from founder line 64 were bred to FVB/NTac mice. Taconic received stock from Sanofi in 2012. The line was embryo transfer derived. In the production colony, the line is maintained by mating homozygous males and females.

Color:

Albino

Species:

Mouse

Initial Publication:



This line is available for immediate cryorecovery. A limited breeding agreement with a license fee is required. Cryorecovery fees are additional.