CRE-Luc GPCR Reporter Mouse, Line 187

Random Transgenic

FVB Background

  • Model #
  • Genotype
  • Nomenclature
  • 11520-F
  • 11520-M
  • Expresses luciferase under the control of the cAMP response element (CRE) primarily in the CNS
  • GPCR signaling through the cAMP pathway can be detected from the target GPCR that is in a native cellular environment with a full complement of associated receptors and membrane constituents
  • Useful for screening in vivo (whole animal), in vitro (primary neuronal cultures), and ex vivo (brain slice) assays
  • Learn more about the CRE-Luc GPCR Reporter Mouse Platform
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

FVB Background


The CRE-Luc GPCR Reporter Mouse, Line 187 was developed by Sanofi. The model was created by microinjecting a transgene containing a 6x CRE promoter, the HSV TK minimal promoter, modified firefly luciferase cDNA from pGL4 and a human growth hormone polyA tail. This transgene was microinjected into FVB/NTac zygotes. The resultant mice from founder line 187 were bred to FVB/NTac mice. Taconic received stock from Sanofi in 2012. The line was embryo transfer derived. The production colony is maintained at homozygous genotype.





Initial Publication:

Conditions of Use of Cre-Luc GPCR Mouse Model (‘Model”)
  • This Model is produced and distributed under rights to intellectual property, which are exclusively licensed to Taconic Biosciences, Inc. ("Taconic"). Taconic sells the Model to purchasers, and grants to each purchaser a right under Taconic's sublicensable rights in such intellectual property to use the purchased Model in consideration of purchaser's agreement to comply with Taconic's Terms and Conditions for the Sale of Products, and the following terms of use: Title to this Model and any biological materials (e.g. cells, nucleic acids, tissues, organs, antibodies, etc.) derived from them ("Biological Materials") remains with Taconic.
  • The Model will be used for research purposes only.
  • The Model will not be bred except to obtain embryos or fetuses required for research purposes (e.g., for obtaining embryonic neurons).
  • Purchasers may not (i) cross-breed the Model, (ii) genetically alter the Model or Biological Materials, and (iii) establish or maintain a culture of any Biological Materials (e.g., cell lines containing luciferase), with the exception of primary cells (e.g., neurons).
  • The Model and Biological Materials derived from it will not be distributed to third parties or used for commercial purposes.
  • Purchasers may not use this Model and/or Biological Materials derived from it in commercially sponsored research or contract research or contract research studies unless a separate Limited Use Agreement is signed.