| Model No. | Nomenclature | Genotype |
|---|---|---|
| 1055 | B6.129S2-Cd4tm1Nik N12 | Inquire for genotype |
Cd4 Knockout
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Overview
Nomenclature: B6.129S2-Cd4tm1Nik N12
- Inactivated Cd4 gene results in the elimination of cell surface expression of Cd4 on T cells.
- Differentiation of cells into the Cd4+ lineage is blocked and there is a decrease in class II restricted activities.
- Useful to study T cell differentation pathways into cytolytic or mature helper T cells.
Origin
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
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Genetics
Guides & Publications
Initial Publication: Killeen N, Sawada S, Littman DR; (1993) Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. The EMBO Journal Vol.12(4) pp1547-1553.
Transit, Housing & Welfare
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Diet
- Licensing
- Pricing - USD
- Pricing - EUR
- Select my Health Standard
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Cd4 Knockout
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
1055
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
1055
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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