| Model No. | Nomenclature | Genotype |
|---|---|---|
| 3737 | B6.129P2-Ccr5tm1Kuz N10 | Inquire for genotype |
Ccr5 Knockout
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Overview
Nomenclature: B6.129P2-Ccr5tm1Kuz N10
- Disruption of the Ccr5 gene results in altered immune responses
- The CC chemokine receptor 5 (CCR5) is the main chemokine receptor for HIV-1 in humans
- Useful for studies of infectious diseases including HIV-1, malaria, influenza and fungal infections as well as autoimmune disorders
Origin
The Ccr5 Knockout mouse was developed by William A. Kuziel in the laboratory of Nobuya Maeda at the University of North Carolina. The model was created by targeting the Ccr5 gene in E14TG2a embryonic stem cells derived from 129P2/Ola mice and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to C57BL/6N for ten generations (N10). Taconic received stock in December 2004. The mice were derived by embryo transfer. The colony was maintained by incrossing homozygous mice.
This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.
Taconic’s Colony Management experts can design a plan to grow your colony faster.
Genetics
Guides & Publications
Initial Publication:
Huffnagle GB, McNeil LK, McDonald RA, Murphy JW, Toews GB, Maeda N, Kuziel WA. Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999, 163(9):4642-6.
Transit, Housing & Welfare
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Diet
- Licensing
- Pricing - USD
- Pricing - EUR
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Ccr5 Knockout
Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.
This model is sold under terms which grant perpetual use rights.
Pricing - USD
3737
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | $23,100.00 | $17,325.00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
Pricing - EUR
3737
| Item | Commercial | Nonprofit |
|---|---|---|
| Cryopreserved Model | €21.000,00 | €15.855,00 |
Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.
Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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