- Disruption of the Ccr5 gene results in altered immune responses
- The CC chemokine receptor 5 (CCR5) is the main chemokine receptor for HIV-1 in humans
- Useful for studies of infectious diseases including HIV-1, malaria, influenza and fungal infections as well as autoimmune disorders
Genetic Background: C57BL/6
Origin: The Ccr5 Knockout mouse was developed by William A. Kuziel in the laboratory of Nobuya Maeda at the University of North Carolina. The model was created by targeting the Ccr5 gene in E14TG2a embryonic stem cells derived from 129P2/Ola mice and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to C57BL/6N for ten generations (N10). Taconic received stock in December 2004. The mice were derived by embryo transfer. The colony was maintained by incrossing homozygous mice.
Huffnagle GB, McNeil LK, McDonald RA, Murphy JW, Toews GB, Maeda N, Kuziel WA. Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999, 163(9):4642-6