| Model No. | Nomenclature | Genotype |
|---|---|---|
| B6-F | C57BL/6NTac | |
| B6-M | C57BL/6NTac |
Black 6 (B6NTac)
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Overview
Nomenclature: C57BL/6NTac
Taconic's B6 Provides Superior Performance
One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it's commonly used as the genetic background for transgenic mouse models. It is also the preferred model for studying diet-induced obesity and the chronic experimental autoimmune encephalomyelitis model of multiple sclerosis.
- Popular research applications include oncology, immunology, metabolic disease, addiction and toxicology
- C57BL/6NTac is the preferred C57BL/6 substrain for generation of genetically engineered models, including by the Knockout Mouse Project (KOMP) and International Mouse Phenotyping Consortium (IMPC)
- The Taconic B6 has superior reproductive performance compared to other B6 substrains: superovulated females yield a high number of embryos and males have higher sperm fertilization rates
- The Taconic C57BL/6NTac has proven more amenable to the development of quality embryonic stem cells compared to other B6 substrains
- Popular strain for syngeneic tumor experiments; with a suite of related strains on the same background for mechanistic studies including Rag2, Rag2/OT-I, Rag2/OT-II and many more
- Historical data shows that hydrocephaly occurs in the C57BL/6 mouse in 0.05% of the population and may not be evident until the animal is more than two months of age.
Availability
Available at the Murine Pathogen Free™, Opportunist Free™, and Germ Free health standards. Order model #B6 for Murine Pathogen Free™ and Opportunist Free™. Order model #GF-B6 for Germ Free. Inquire about ordering mice positive or negative for Segmented Filamentous Bacteria (SFB).Origin
Genetics
Guides & Publications
Applications & Therapeutic Areas
- ADMET
- Microbiome
- Model Generation Solutions
- Neuroscience
- Oncology & Immuno-Oncology
- Psychiatric Disorders
- Transgenic Model Generation Support
- Vaccine Research
- Autoimmune Disease
- Cardiovascular Disease
- Diabetes
- Immunology
- Infectious Disease
- Inflammation
- Inflammatory Bowel Disease
- Metabolic Disease
Transit, Housing & Welfare
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B6 males at 7+ weeks of age are packed as cagemates, without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommend that customers do NOT recombine 7+ week old B6 males from different Taconic Transit Cages into the same cage at or after unpacking.
Packing Practices
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
- Services
Data
Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6NTac mice
Representative data for Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6NTac provided by Biomodels. Download the full data package.
C57BL/6NTac substrains carry the Crb1Rd8 mutation.Retinal degeneration 8, is a mild form of retinal degeneration that affects vision. This recessive mutation is a single base pair mutation in the Crb1 gene, Crb1Rd8 (Mehalow et al. 2003) The onset of the phenotype appears to be between 2 and 6 weeks of age (Pritchett-Corning, 2012).
C57BL/6J mice present a deletion (~17 Kbp) in the Nicotinamide Nucleotide Transhydrogenase (Nnt) gene. Nnt is a transmembrane protein that catalyzes the inter conversion of NADH and NADPH in the mitochondria. Studies suggest that the presence of Nnt is essential for mitochondrial defense against oxidative stress and for normal cellular metabolism (Huang et al. 2006). Taconic’s C57BL mice, including C57BL/6JBomTac, C57BL/6NTac and C57BL/10SgSnAiTac, or our B6D2F1 and B6129F1, do not carry the Nnt mutation which is present in C57BL/6J sub-strain.
C57BL/6J mice present a deletion (~17 Kbp) in the Nicotinamide Nucleotide Transhydrogenase (Nnt) gene. Nnt is a transmembrane protein that catalyzes the inter conversion of NADH and NADPH in the mitochondria. Studies suggest that the presence of Nnt is essential for mitochondrial defense against oxidative stress and for normal cellular metabolism (Huang et al. 2006). Taconic’s C57BL mice, including C57BL/6JBomTac, C57BL/6NTac and C57BL/10SgSnAiTac, or our B6D2F1 and B6129F1, do not carry the Nnt mutation which is present in C57BL/6J sub-strain.
Physiologic
Immunology
Reproductive Data
- Average litter size: 6-8
- Mean # litters/female: 7
- Mean age breeder retired: 10 months
- Mean # days to litter: 22
For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. For orders sourced from US or Denmark a production minimum 3 gram span is accepted. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.
n = 500 per sex at MPF, RF and EF health standards from all global colonies. GF mice will typically weigh slightly less than the weights above.
High and low represents mean +/- 2 standard deviations
Based on sample size, the charts above represent ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.
Customize this chart by clicking the legend elements.
- Licensing
- Pricing - USD
- Pricing - EUR
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Licensing
Terms of Sale and Use for Black 6 (B6NTac)
Germ Free Black 6 are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services and the following terms of use:- For-profit purchasers may not breed Germ Free Black 6 except to obtain embryos or fetuses for research use.
- Non-profit purchasers may breed Germ Free Black 6 for use in projects at purchaser's institution and on behalf of non-profit researchers only.
- Germ Free Black 6, progeny and materials derived from them will not be distributed to third parties.
Pricing - USD
Opportunist Free (OF) Health Standard
B6 Female
B6-F
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $54.00 |
| 5 to 6 | $67.00 |
| 7 to 8 | $78.00 |
| 9 to 10 | $87.00 |
Specialized Inventory
| B6-FL | Quantity 1 - 199 |
| Female With Litter | $434.00 |
Specialized Inventory
| B6-TP | Quantity 1 - 199 |
| Timed Pregnant Female | $511.00 |
Specialized Inventory
| B6-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $355.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
Specialized Inventory
| B6-RF | Quantity 1 - 199 |
| Retired Female Breeder | $93.00 |
B6 Male
B6-M
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | $54.00 |
| 5 to 6 | $67.00 |
| 7 to 8 | $78.00 |
| 9 to 10 | $87.00 |
Specialized Inventory
| B6-RM | Quantity 1 - 199 |
| Retired Male Breeder | $93.00 |
Murine Pathogen Free (MPF) Health Standard
B6 Female
B6-F
| Age in Weeks | Quantity 1 - 199 | Quantity 200 - 999 |
| 3 to 4 | $31.00 | $28.00 |
| 5 to 8 | $39.00 | $33.00 |
| 9 to 10 | $45.00 | $41.00 |
| 11 to 12 | $52.00 | $46.00 |
Specialized Inventory
| B6-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $247.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
Specialized Inventory
| B6-FL | Quantity 1 - 199 |
| Female With Litter | $325.00 |
Specialized Inventory
| B6-TP | Quantity 1 - 199 |
| Timed Pregnant Female | $347.00 |
Specialized Inventory
| B6-RF | Quantity 1 - 199 |
| Retired Female Breeder | $55.00 |
B6 Male
B6-M
| Age in Weeks | Quantity 1 - 199 | Quantity 1 - 999 | Quantity 200 - 999 |
| 3 to 4 | $31.00 | $28.00 | |
| 5 to 8 | $39.00 | $33.00 | |
| 9 to 10 | $45.00 | $41.00 | |
| 11 to 12 | $59.00 | $46.00 | |
| 13 to 14 | $70.00 | ||
| 15 to 16 | $80.00 | ||
| 17 to 18 | $91.00 | ||
| 19 to 20 | $102.00 | ||
| 21 to 22 | $113.00 | ||
| 23 to 24 | $123.00 | ||
| 25 to 26 | $134.00 | ||
| 27 to 31 | $156.00 | ||
| 32 to 36 | $177.00 | ||
| 37 to 40 | $199.00 | ||
| 41 to 44 | $220.00 | ||
| 45 to 48 | $241.00 | ||
| 49 to 52 | $262.00 |
Specialized Inventory
| B6-RM | Quantity 1 - 199 |
| Retired Male Breeder | $55.00 |
Germ Free (GF) Health Standard
B6 Female
B6-F
| Age in Weeks | Quantity 1 - 29 | Quantity 30 - 999 |
| 4 | $587.00 | $559.00 |
| 5 | $653.00 | $623.00 |
| 6 | $678.00 | $644.00 |
| 7 | $707.00 | $673.00 |
| 8 | $737.00 | $701.00 |
| 9 | $781.00 | $745.00 |
| 10 | $825.00 | $785.00 |
Specialized Inventory
| B6-RF | Quantity 1 - 199 |
| Retired Female Breeder | $1,112.00 |
Specialized Inventory
| B6-NP | Quantity 1 - 999 |
| Non-Pregnant Retired Female Breeder | $1,332.00 |
Specialized Inventory
| B6-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | $4,225.00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
B6 Male
B6-M
| Age in Weeks | Quantity 1 - 29 | Quantity 30 - 999 |
| 4 | $587.00 | $559.00 |
| 5 | $653.00 | $623.00 |
| 6 | $678.00 | $644.00 |
| 7 | $707.00 | $673.00 |
| 8 | $737.00 | $701.00 |
| 9 | $781.00 | $745.00 |
| 10 | $825.00 | $785.00 |
Specialized Inventory
| B6-RM | Quantity 1 - 199 |
| Retired Male Breeder | $1,112.00 |
Pricing - EUR
Opportunist Free (OF) Health Standard
B6 Female
B6-F
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €34,00 |
| 5 to 6 | €37,00 |
| 7 to 8 | €41,00 |
| 9 to 10 | €47,00 |
Specialized Inventory
| B6-RF | Quantity 1 - 199 |
| Retired Female Breeder | €52,00 |
B6 Male
B6-M
| Age in Weeks | Quantity 1 - 999 |
| 3 to 4 | €33,00 |
| 5 to 6 | €36,00 |
| 7 to 8 | €39,00 |
| 9 to 10 | €49,00 |
Specialized Inventory
| B6-RM | Quantity 1 - 199 |
| Retired Male Breeder | €57,00 |
Murine Pathogen Free (MPF) Health Standard
B6 Female
B6-F
| Age in Weeks | Quantity 1 - 199 | Quantity 200 - 999 |
| 3 to 4 | €21,00 | €20,00 |
| 5 to 6 | €23,00 | €21,00 |
| 7 to 8 | €25,00 | €23,00 |
| 9 to 10 | €29,00 | €27,00 |
| 11 to 12 | €36,00 | €33,00 |
Specialized Inventory
| B6-FL | Quantity 1 - 199 |
| Female With Litter | €192,00 |
Specialized Inventory
| B6-TP | Quantity 1 - 999 |
| Timed Pregnant Female | €276,00 |
Specialized Inventory
| B6-RF | Quantity 1 - 199 |
| Retired Female Breeder | €34,00 |
B6 Male
B6-M
| Age in Weeks | Quantity 1 - 199 | Quantity 200 - 999 |
| 3 to 4 | €21,00 | €20,00 |
| 5 to 6 | €23,00 | €21,00 |
| 7 to 8 | €25,00 | €23,00 |
| 9 to 10 | €29,00 | €27,00 |
| 11 to 12 | €36,00 | €33,00 |
| 13 to 14 | €45,00 | |
| 15 to 16 | €55,00 | |
| 17 to 18 | €61,00 | |
| 19 to 20 | €69,00 | |
| 21 to 22 | €80,00 | |
| 23 to 24 | €86,00 | |
| 25 to 26 | €94,00 | |
| 27 to 31 | €109,00 | |
| 32 to 36 | €122,00 | |
| 37 to 40 | €136,00 | |
| 41 to 44 | €147,00 | |
| 45 to 48 | €162,00 | |
| 49 to 52 | €175,00 |
Specialized Inventory
| B6-RM | Quantity 1 - 199 |
| Retired Male Breeder | €36,00 |
Germ Free (GF) Health Standard
B6 Female
B6-F
| Age in Weeks | Quantity 1 - 29 | Quantity 30 - 999 |
| 4 | €585,00 | €558,00 |
| 5 | €655,00 | €623,00 |
| 6 | €675,00 | €644,00 |
| 7 | €705,00 | €673,00 |
| 8 | €735,00 | €700,00 |
| 9 | €781,00 | €745,00 |
| 10 | €824,00 | €784,00 |
Specialized Inventory
| B6-UP | Quantity 1 - 199 |
| Untimed Pregnant Female | €3.137,00 |
*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.
B6 Male
B6-M
| Age in Weeks | Quantity 1 - 29 | Quantity 30 - 999 |
| 4 | €585,00 | €558,00 |
| 5 | €655,00 | €623,00 |
| 6 | €675,00 | €644,00 |
| 7 | €705,00 | €673,00 |
| 8 | €735,00 | €700,00 |
| 9 | €781,00 | €745,00 |
| 10 | €824,00 | €784,00 |
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Trial an Animal Model for Quality & Compatibility Assurance
As longtime facilitators of animal-based research, we understand the importance of aligning your project goals and procurement priorities to support advancements in your research.
- Evaluate a specific model strain, before making any financial investment
- Request up to 20 animals from one of the strains listed below, to test for quality, consistency, and suitability for your experimental purpose
- Enjoy free ground shipping, where applicable (see table for more details)*
Hear From our Scientists
“Hooke uses the Taconic B6 because we get more consistent disease development for Experimental Autoimmune Encephalomyelitis (EAE) than when using mice from other vendors.”
— Hooke Laboratories
“Taconic Biosciences had provided invaluable support to our course on "Mouse Development, Stem Cells & Cancer". It would be difficult to continue to teach this course at the level we currently do without Taconic's expertise and C57BL/6 mice.”
— Cold Spring Harbor
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