- Foxn1nu mutation backcrossed to the BALB/cAnNTac inbred strain for equivalent of nine generations
- Taconic maintains this valuable model at two health designations, Defined Flora from gnotobiotic isolators and Restricted Flora™ from Isolated Barrier Units™
- The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues. Tissues from the BALB/c Nude can be transplanted onto normal BALB/c mice.
- The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues.
- Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. Heterozygous nudes were originally thought to have normal immune systems, but in fact have immune alterations such as reduced bone marrow stem cells and lower thymus weights. Heterozygous nudes may thus not be appropriate for use as sentinels. They may be used in PK/dosing studies.
Genetic Background: BALB/c Background
Origin: Taconic received the BALB/c Nude Spontaneous Mutant model from the NIH Animal Genetic Resource in 1980. The mice were backcrossed eighteen generations. The mice are maintained by incrossing non-brother x sister mice.
Availability: Live production in Denmark of this model ceased on November 20, 2015. This model continues to be available from live colonies in the US.
Genetics: Refer to the BALB/c (background strain) for inbred genetic data.
Coat Color Loci: Tyrc, Tyrp1b