BALB/c

Inbred

BALB/c Inbred Mouse Model
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  • Model #
  • Genotype
  • Nomenclature
  • BALB-F
    BALB/cAnNTac
  • BALB-M
    BALB/cAnNTac

  • A general purpose inbred strain for many different research disciplines.
  • Often used for the production of monoclonal antibodies using hybridomas of BALB/c spleen cell origin.
  • It exhibits good breeding performance and long reproductive life span.
  • See Phenotypic Data below for a note regarding induction of liver fibrosis with CCl4.

Origin:

The BALB/c inbred model was first bred by Bagg et al. MacDowell received stock from Bagg in 1923 which were then inbred. Snell received stock from MacDowell in 1932. Andervont received stock from Snell in 1935. NIH received stock at F72 from Andervont in 1951. Taconic's BALB/c mice originated from NIH at F184 prior to 1988. Taconic received litters at F184 from the NIH Animal Genetic Resource in 1997. The mice were derived by embryo transfer in 1998. The Taconic foundation colony was at F229 in 2005.


Genetics:

  • Strain Profile: Acy1s, Alada, Carb, Cas1a, Cd5b, Cd72b, Cd8ab, Cd8b1b, Ce2a, Es1b, Esda, pi1a, Gusa, H6pdb, Hbab, Hbbd, Hc1, Idh1a, Mod1a, Mup1a, Pepca, Pgm1a, Thy1b, Trfb, Ptprcb
  • Immunology: H2-T18c, H2d

Coat Color Loci:

Tyrp1b, Tyrc

Color:

Albino

Species:

Mouse


Terms of Sale and Use for BALB/c

Germ Free BALB/c are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services and the following terms of use:

  • For-profit purchasers may not breed Germ Free BALB/c except to obtain embryos or fetuses for research use.
  • Non-profit purchasers may breed Germ Free BALB/c for use in projects at purchaser's institution and on behalf of non-profit researchers only.
  • Germ Free BALB/c, progeny and materials derived from them will not be distributed to third parties.
Murine Pathogen Free™ and Opportunist Free BALB/c mice are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services.

For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model, except at the GF health standard. A minimum 3 gram span is required. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.

n = 500 per sex at MPF health standard from all global colonies. GF mice will typically weigh slightly less than the weights above.
High and Low represent mean +/- 2 standard deviations.
Based on sample size the charts above represent ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves. Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.

Average litter size: 7
Customers have reported that Taconic's BALB/cAnNTac mouse exhibits unexpected sensitivity in the first week of induction of liver fibrosis through intraperitoneal injections of carbon tetrachloride (CCl4), including within low dose groups (0.0625 μL/g). Clinical symptoms included weight loss exceeding 20% and poor body condition score. It is unclear if this is a response to the CCl4, the selected dosing vehicle, animal manipulation, environmental/microbiome factors, or a combination of these. Taconic recommends that customers validate their CCl4 fibrosis protocols in a pilot study, and consider acclimatory vehicle dosing prior to initiating CCl4 administration.
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