B6.SJL

Congenic

B6.SJL Congenic Mouse Model
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This model is impacted by a newly discovered spontaneous mutation in the Thyroglobulin (Tg) gene. It will be removed over time through selective breeding. See the Fact Sheet for more information.

  • Model #
  • Genotype
  • Nomenclature
  • 4007-F
    sp/sp
    B6.SJL-Ptprca/BoyAiTac
  • 4007-M
    sp/sp
    B6.SJL-Ptprca/BoyAiTac

  • Genetically similar to the C57BL/NTac strain except that it carries the Ptprca allele (protein-tyrosine phosphatase, receptor type c locus previously known as CD45.1, Ly5.1) and the Pep3b allele from the SJL/J strain
  • The unique lymphocyte cell surface antigen produced by Ptprca makes this strain useful for immunological adoptive transfer experiments and useful as a background for transgenic and knockout models used in adoptive transfer studies
  • Backcrossed to the C57BL/6NTac strain to NE8 as assessed by SNP testing.

Origin:

The B6.SJL Congenic model was developed by Boyse et al in 1975 by intercrossing C57BL/6Boy mice to SJL/J mice. Taconic received stock from the NIAID in 1995. The mice were derived by embryo transfer into the NIAID Transgenic Mouse Repository. The mice were backcrossed by Boyse to a C57BL/6Boy inbred background to select for SJL antigen type (now referred to as Ptprca or Ly5.1). Refreshed in 2007 from NIAID stock. Further backcrossed to the C57BL/6NTac background to NE8.


Color:

Black

Species:

Mouse


Taconic cannot routinely accept orders by weight for this model due to colony size. Please inquire for options if weight is critical for your experiment.

n= 50 per sex at MPF health standards from US colonies. Data collected 2012-13.
High and Low represent mean +/- 1 standard deviation.
Based on sample size the charts above represents ~65% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.

Average litter size: 5
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