B2m (β2m)

Genetic Background:

C57BL/6 Background

Origin:

The B2m mouse was developed in the laboratory of Rudolf Jaenisch at the Whitehead Institute. The model was created by targeting the B2m gene in D3 ES cells and injecting the targeted cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed to C57BL/6 for five generations (N5). GenPharm International received stock from the Jaenisch lab in 1991. Taconic received stock in February 1994. The mice were then backcrossed seven generations (N12) to C57BL/6NTac and derived by embryo transfer. Heterozygotes were intercrossed to homozygosity. The colony was maintained through incrossing of homozygotes.

Genetics:

Wild type for Nnt mutation

Color:

Black

Species:

Mouse

Initial Publication:

Zijlstra M, Bix M, Simister NE, Loring JM, Raulet DH, Jaenisch R. (1990) β2-Microglobulin deficient mice lack CD4-8+ cytolytic T cells, Nature, 344(6268):742-746.

Animal Diet:

NIH #31M Rodent Diet

To purchase this EZcohort model, sign the terms of sale (choose from the list below) and email it directly to info@taconic.com with a purchase order for the purchase price:

This model is sold under terms which grant perpetual use rights.