Tnk1

Constitutive Knockout

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This line is cryopreserved and requires cryorecovery.

Model #
Genotype
Nomenclature

TF1938

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MGI:1930958

Model Description

Gene Description: tyrosine kinase, non-receptor, 1

Synonyms: Kos1, Tnk1a, Tnk1b

Gene Family:

Kinase

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_031880

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11114734
http://www.ncbi.nlm.nih.gov/pubmed/12466851
http://www.ncbi.nlm.nih.gov/pubmed/12789265
http://www.ncbi.nlm.nih.gov/pubmed/16141072

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.

For standard orders clients will receive:

A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background.
Validated genotyping protocols
Animal health data

Terms of Sale

Terms of Sale for the Knockout Repository:

Terms of Sale for Phenotypic Data Packages (Basic and Comprehensive):

Pricing

Business Type	Price per Line $/€	Price per Line for Comprehensive Phenotype Data $/€
For Profit (Commercial)	$20,000 €18,200	$10,000 €9,100
Nonprofit	$15,000 €13,650	$8,000 €7,280

Basic Phenotype Package: $5,000/€4,550

KOR models are invoiced upon shipment. Once orders are placed, full purchase price will be applied if order is cancelled.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.