Sirt5

Gene Family:

Enzyme

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_178848

Mutation Type:

Trapped

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/11217851 http://www.ncbi.nlm.nih.gov/pubmed/12466851 http://www.ncbi.nlm.nih.gov/pubmed/17923681 http://www.ncbi.nlm.nih.gov/pubmed/18054327

 

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.