Chrna5

Constitutive Knockout

Cryopreserved Model
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This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • TF1583
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    MGI:87889

Gene Description: cholinergic receptor, nicotinic, alpha polypeptide 5

Synonyms: Acra5, Acra-5

Gene Family:

Ion Channel

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_176844

Mutation Type:

Targeted

Species:

Mouse


The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyrc-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyrc-Brd background.

For standard orders clients will receive:

  • A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background.
  • Validated genotyping protocols
  • Animal health data

Business TypePrice per Line $/€Price per Line for Comprehensive Phenotype Data $/€
For Profit (Commercial)$23,000
€20,000		$10,000
€9,100
Nonprofit$17,000
€15,000		$8,000
€7,280
Basic Phenotype Package: $5,000/€4,550

KOR models are invoiced upon shipment. Once orders are placed, full purchase price will be applied if order is cancelled.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.
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