Chrna5

Gene Family:

Ion Channel

Genetic Background:

129/SvEv-C57BL/6

Gene Accession Number:

NM_176844

Mutation Type:

Targeted

Species:

Mouse

Initial Publication:

http://www.ncbi.nlm.nih.gov/pubmed/1505988
http://www.ncbi.nlm.nih.gov/pubmed/8748389
http://www.ncbi.nlm.nih.gov/pubmed/8838678
http://www.ncbi.nlm.nih.gov/pubmed/9096119
http://www.ncbi.nlm.nih.gov/pubmed/9495872
http://www.ncbi.nlm.nih.gov/pubmed/10765

The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.

The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyr^c-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyr^c-Brd background.