Constitutive Knockout

Cryopreserved Model
This line is cryopreserved and requires cryorecovery.

  • Model #
  • Genotype
  • Nomenclature
  • TF4147
Gene Description: calcium channel, voltage-dependent, T type, alpha 1G subunit

Synonyms: a1G, Cav3.1d, mKIAA1123

Gene Family:


Genetic Background:


Gene Accession Number:


Mutation Type:




The knockout models are designed to be null alleles. Due to compensatory genetic mechanisms, knockout status cannot be guaranteed and will have to be confirmed by the customer. Some validation data may be already available – please inquire for more details.
Access to this model requires a license agreement.
  • Nonprofit users: agreement fees for this model are $5,000 (€4,000)/year for the first year term and $1,500/year for renewal terms. Nonprofit users may breed with Taconic or at their own facility.
  • For-profit users: agreement fees for this model are $30,000 (€24,000)/year and contract production at Taconic is required.
Please contact Taconic to discuss your usage needs.

The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
Japanese Patent No. 3,753,321
US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
EU Patent No. 1,338,198
Japanese Trademark Reg. No. 4,823,423
US Trademark Reg. No. 3,118,040
EU Trademark Reg. No. 3,736,758
The KO Repository lines exist as cryopreserved materials. Cohorts can typically be produced and delivered to the customer within 14-16 weeks of order receipt. For most lines, the mouse ES cells used in generating the model are of the 129S5 strain. Lines are stored primarily as cryopreserved sperm on a mixed 129S5 x C57BL/6J-Tyrc-Brd background. Lines are recovered using cryopreserved sperm and C57BL/6NTac oocyte donors. Some lines are stored as cryopreserved embryos and when revitalized will result in a 129/S5 x C57BL/6J-Tyrc-Brd background.

For standard orders clients will receive:

  • A minimum of four (4) mutant mice, heterozygous for the selected mutation on a mixed 129S5;B6 background.
  • Validated genotyping protocols
  • Animal health data
Business TypePrice per Line $/€Price per Line for Comprehensive Phenotype Data $/€
For Profit (Commercial)$24,000
Basic Phenotype Package: $5,000/€4,550

KOR models are invoiced upon shipment. Once orders are placed, full purchase price will be applied if order is cancelled.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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