NOG Portfolio

A Unique Portfolio with Broad Applications Built Upon the Super Immunodeficient CIEA NOG mouse®

The NOG mouse is a widely used and versatile super immunodeficient mouse which offers many advantages over standard nude and scid strains, particularly for engraftment of challenging cell lines, patient-derived xenografts, and immune system humanization.

The NOG mouse is the base of a flexible platform which includes a variety of next-generation models which have specific utility as well as several different types of humanized immune system (HIS) models.

The Taconic NOG Portfolio of super immunodeficient and humanized immune system mouse models

  • CIEA NOG mouse®: A super immunodeficient mouse with unparalleled ability to engraft human cells and tissues, including human hematopoietic lineages. Applications in oncology, infectious disease, autoimmune disease and more.
2nd generation models are based on the CIEA NOG mouse® with further genetic modifications. Examples of such modifications include expression of human cytokines that support myeloid lineage development and modifications that enable reconstitution of human liver.

  • NOG-EXL: NOG with expression of transgenic human GM-CSF and human IL3. Upon engraftment with human hematopoietic stem cells, develops both human lymphoid and myeloid lineages. Useful for studies involving human myeloid cells, including immuno-oncology and allergy applications; host for acute myeloid leukemia (AML) PDX.
  • hIL-2 NOG: Supports research involving human T cells, including Graft vs. Host Disease, CAR-T cell efficacy studies, tumor infiltrating lymphocytes (TILs).
  • hIL-6 NOG: Useful for studies involving human monocytes and macrophages, including tumor-associated macrophages (TAMs); host for multiple myeloma (MM) PDX.
  • hIL-15 NOG: Widely used for studies involving human NK cells, including immuno-oncology and Graft vs. Host Disease applications.
  • B2m-NOG: provides prolonged study window following engraftment of human PBMCs for immuno-oncology and other efficacy studies.
  • TK-NOG: NOG with transgenic expression of thymidine kinase under control of liver restricted albumin promoter. Used for reconstitution of the human liver.
The FcResolv™ NOG family of strains is specifically designed for studies using antibody-based drugs to reduce false positive and false negative results mediated by mouse FcγRs.
  • FcResolv™ NOG: a super immunodeficient NOG mouse which has a further reduction in residual murine immune activity via ablation of mouse Fcγ receptors in order to reduce experimental confounders.
  • FcResolv™ hIL-15 NOG: an FcResolv™ NOG mouse which expresses human IL-15 to support engraftment of human NK cells.
  • FcResolv™ huNOG: A humanized immune system FcResolv™ NOG mouse supporting long-term engraftment of human lymphoid cells.
  • FcResolv™ huNK hIL-15 NOG: A humanized immune system mouse model based on the FcResolv™ hIL-15 NOG mouse,which supports abundant human NK cells.
  • huNOG-EXL: A humanized immune system mouse supporting both myeloid and lymphoid cells. Available as huNOG-EXL SA or huNOG-EXL EA.
    • huNOG-EXL SA: For researchers who want access to live inventory for immediate delivery, the huNOG-EXL SA (Standard Access) is the ideal model, particularly for experiments with shorter timelines or studies that must start as soon as possible.
    • huNOG-EXL EA: For researchers with certain experimental designs or logistical hurdles, early access to huNOG-EXL mice soon after engraftment may be advantageous, particularly for longer study timelines which may push the bounds of the useful study window in these mice.
  • huNOG: A humanized immune system mouse with long-term engraftment of human myeloid cells.
  • huPBMC-B2m-NOG: A model for investigation of adult, mature T cells with a prolonged study window relative to huPBMC-NOG.
  • huPBMC-NOG: A short-term model for investigation of adult, mature T cells.


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