2nd generation models are based on the CIEA NOG mouse
® with further genetic modifications. Examples of such modifications include expression of human cytokines that support myeloid lineage development and modifications that enable reconstitution of human liver.
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NOG-EXL: NOG with expression of transgenic human GM-CSF and human IL3. Upon engraftment with human hematopoietic stem cells, develops both human lymphoid and myeloid lineages. Useful for studies involving human myeloid cells, including immuno-oncology and allergy applications; host for acute myeloid leukemia (AML) PDX.
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hIL-2 NOG: Supports research involving human T cells, including Graft vs. Host Disease, CAR-T cell efficacy studies, tumor infiltrating lymphocytes (TILs).
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hIL-6 NOG: Useful for studies involving human monocytes and macrophages, including tumor-associated macrophages (TAMs); host for multiple myeloma (MM) PDX.
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hIL-15 NOG: Widely used for studies involving human NK cells, including immuno-oncology and Graft vs. Host Disease applications.
- B2m-NOG: provides prolonged study window following engraftment of human PBMCs for immuno-oncology and other efficacy studies.
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TK-NOG: NOG with transgenic expression of thymidine kinase under control of liver restricted albumin promoter. Used for reconstitution of the human liver.