NOG Portfolio

Modern oncology, infectious disease, and immunology research requires specialized mouse models. Humanized Mice are precision research mouse models that provide opportunities for scientists to better understand and develop treatments for some of today’s most prevalent diseases. Such in vivo models also hold great potential for improving the predictability of human response to drugs later in clinical development.

What our customers say:

“Experimental Pharmacology & Oncology (EPO) GmbH uses 1^st and 2^nd generation NOG mice provided by Taconic for its preclinical oncology service. These mice are included in novel concepts for the development of personalized treatment options and especially suited for humanization strategies. We are very satisfied with the quality of mice, the reliability of shipment and the high level of scientific support. Further, we very much appreciate the competent and always friendly communication.”

Experimental Pharmacology & Oncology (EPO) GmbH

What our customers say:

“Working with Taconic has been a great pleasure for Pharmatest. We are impressed with the high quality services, top-level scientific support, and fast and clear communication. By using humanized mice provided by Taconic, we have been able to establish more predictive animal models to support immuno-oncology therapy development.”

Dr. Jenni Bernoulli, COO at Pharmatest

Taconic Bioscience's NOG Portfolio collection of mice are ideal for these studies. The portfolio consists of three sets of NOG mouse models.

Core models

These models are available immediately in large quantities.

CIEA NOG mouse®: Super immunodeficient model lacking mature T, B, and NK cells on an NOD background;
CIEA BRG mouse: Super immunodeficient model lacking mature T, B, and NK cells congenic on BALB/c background; most useful for studies requiring clinically relevant radiation doses

Next generation NOG models

Next generation models are based on the CIEA NOG mouse® with further genetic modifications. Examples of such modifications include expression of human cytokines that support myeloid lineage development, modifications that enable reconstitution of human liver, and the deletion of mouse major histocompatibility complex genes to study human MHC reactive T cells.

B2m-NOG
NOG-EXL (hGM-CSF/hIL-3 NOG): NOG with expression of transgenic human GM-CSF and human IL3.
- Used for hematopoietic stem cell engraftment that supports the development of an improved human immune system.
TK-NOG: NOG with transgenic expression of thymidine kinase under control of liver restricted albumin promoter.
- Used for reconstitution of the human liver.
hIL-2 NOG
hIL-6 NOG
hIL-15 NOG