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COVID-19 Q&A with Dr. Alessandro Sette

Defining the immune response to SARS-CoV-2 is critical for development of vaccines against COVID-19 and may also shed light on the variable disease severity observed in humans. This short Q&A session with Dr. Alessandro Sette, an expert with more than 30 years research experience on the immune system, highlights cutting edge research on the SARS-CoV-2 coronavirus. Dr. Sette introduces the concept of the human leukocyte antigen (HLA) system and its role in the immune system. He reviews his recent work on identifying likely SARS-CoV-2 epitopes based on the substantial existing data from on the closely-related SARS-CoV virus. Finally, Dr. Sette addresses potential next steps towards vaccine development, including the important role of preclinical animal models in vaccine research.

Alessandro Sette, Dr. Biol.Sci.

sette.jpgLa Jolla Institute

  • Professor in the Center for Infectious Disease and Vaccine Center
  • A leader in the field of T cell epitope-MHC interactions, beginning with his contribution to the discovery of the biological function of MHC in the mid 80s to mid 90s
Learn more about the HLA system and transgenic HLA mice for vaccine research.

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