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D Agouti

TRADITIONAL INBRED RATS

Model Number	Zygosity	Nomenclature
DA-F		DA/MolTac
DA-M		DA/MolTac

Model Description

Widely used in transplantation studies, often with the Lewis rat
Susceptible to experimentally induced arthritis
Also susceptible to the induction of autoimmune thyroiditis and experimental allergic encephalomyelitis.
Males exhibit a high incidence of bladder tumors and females exhibit a high incidence of hormone-dependent endometrial adenocarcinoma.

Origin: The D Agouti inbred model was developed by the Agricultural Research Council Institute of Animal Physiology at Cambridge. Zentralinstitut f�r Versuchsteirzucht of Hannover Germany received stock. M&B A/S (now Taconic Europe) received stock in 1990. The rats were derived by embryo transfer in 2004 at Taconic US. The Taconic foundation colony was at F28 in 2005.

Color: Agouti

Genetics:

Strain Profile: Aco1^b, Alp^b, Anpep^b, Es1^b, Es2^a*, Es3^a, Es4^b, Es6^a, Es7^b, Es9^a, Es10^a, Es14^a, Es15^a, Es18^a, Fh1^b, Hbb^b, Pgd^b, Svp1^a
Immunology: RT1-A^a

* Genetic monitoring of the foundation colony following derivation identified a mobility variant of Es2 and ongoing evaluation of this marker will continue.

Animal Diet: NIH #31M Rodent Diet

Growth Chart

Phenotyping

Sexual Maturity: females at approximately 8 - 10 weeks of age
Pregnancy: males at approximately 10 - 12 weeks of age approximately 21 - 23 days
Litter size: 5 - 7 average
Pregnancy % approximately 60% of the mated animals