FELASA Congress

June 13-16, 2016
Brussels, Belgium

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Microbiome & Mice 2016: Advancing Microbiome Research Symposium

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  • Preclinical Immuno-Oncology Animal Models

    Immuno-oncology - triggering a patient's own immune system to attack their cancer - is sweeping through all levels of oncology research, from academia to biotech and pharma. Silicon Valley mogul Sean Parker, co-founder of Napster and first president of Facebook, pledged $250 million to... Read more

  • Patient-derived Xenografts of Hematological Malignancies Webinar Review

    Different Engraftment Strategies* Dr. Julia Schueler of Oncotest presented a webinar exploring her work with patient-derived xenografts (PDX) of hematological malignancies as model systems for drug development and tumor biology research. PDX models of hematological origin provide the same advantages as solid tumor PDX... Read more

  • Review: Humanized Mouse Model Research Symposia

    Humanized mouse models are critical tools for basic research, modeling of certain human-specific infectious diseases, efficacy testing of immunotherapy approaches, and safety assessment for large molecule therapeutics. Taconic Biosciences recently hosted the symposium series "Advanced Preclinical Models for Immuno-oncology and Infectious Disease" in several European... Read more

  • Production of Germ-Free Mice: Then and Now

    On September 26, 1949, Life Magazine showed the world "a strange, new sterile laboratory at Notre Dame", where animal care technicians in diving suits submerged themselves in germicidal tanks, and animals were raised in sealed environments. A Strange New Laboratory Scientists were curious whether... Read more

  • Patient-Derived Xenografts Q&A with Dr. Els Hermans

    Dr. Els Hermans, whose work on the Trace platform at KU Leuven is streamlining the oncology R&D pipeline, presented a webinar focused on the application of patient-derived xenograft models (PDX) in translational cancer research. Her presentation on use of PDX models to close the gap... Read more

  • Quality and study design considerations for rasH2 model - an alternative model for carcinogenic risk assessment

    75% of mouse carcinogenicity studies submitted to the FDA utilize the rasH2 mouse model (Tg.rasH2), a model accepted by the FDA as an alternative to the two-year bioassay for predicting human carcinogenic risk. In an evolving carcinogenicity testing landscape, with the utility of two-year... Read more

  • Where You Source Your Lab Mice Matters

    Has a study ever performed as expected the first time you run it, but the results stop making sense in subsequent trials? You used the same strain of mice, same sex and same age. The only variable appears to be the vendor...what could be happening?... Read more

  • Should Your Fecal Microbiota Transplantation Study Use Germ-Free Mice?

    Are you planning on doing some fecal microbiota transplant studies? Unsure whether to use germ-free or antibiotic treated mice for your studies? In a recent review paper (Gut Microbes, March 2016), Randi Lundberg and her coauthors present the pros and cons for using antibiotic-treated... Read more