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Copy Number Variation and Novel Psychiatric Disease Mouse Lines

Tuesday, December 13th, 2016
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  • Investigating Tau Proteins in Alzheimer's Disease Mouse Models

    Despite tau proteins having essential roles in neurodegeneration and amyloid-mediated neurotoxicity, Alzheimer's disease (AD) therapeutic development has largely focused on amyloid-beta. Recent investigations, in humans and rodent Alzheimer's Disease models, suggest specific tau species might be major pathological contributors to AD progression and, as such,... Read more

  • Microbiome Affects Severity in Mouse Model of Malaria

    Malaria is a serious global health hazard, with 214 million new cases worldwide in 2015 according to the World Health Organization. Infection by Plasmodium species can result in a range of disease severity, from asymptomatic infection through severe disease and death. A comparison between mouse... Read more

  • Does Vascular Catheterization in Mice Impact Health?

    Vascular catheterization is commonly used to sample blood and administer compounds to mice and rats, but does it have physiological impact? Researchers may assume that catheterization and automated blood sampling has no effect on the test subject, but a new study sheds doubt on that... Read more

  • Animal Models for Zika Virus Infection

    Researchers at the Department of Medicine, Washington University School of Medicine published a paper demonstrating that Zika virus could be transmitted sexually. "In addition to transmission by mosquitoes," they report, "ZIKV can be detected in the seminal fluid of affected males for extended periods of... Read more

  • Combination Immunotherapy Research with Syngeneic Tumor Models

    In combination immunotherapy research, the goal is to coach multiple aspects of the body's own immune system to recognize and destroy cancerous cells. This strategy holds the promise of treating advanced tumors and keeping them at bay, with better responses and fewer side effects compared... Read more

  • Targeting APOE4 for Alzheimer's Disease Therapies

    Past research efforts, focused on Alzheimer's disease (AD) pathology and the genetics of familial AD, led to the discovery of important AD-related proteins, including amyloid-beta (Aβ) and tau. However, efforts to develop AD therapies based on targeting Aβ and tau have largely failed. Years of... Read more

  • Using HLA Transgenic Mice to Investigate Novel T Cell Therapies

    Recent clinical successes in immuno-oncology, coupled with developments in genetically engineered mouse models, are driving interest in utilizing new aspects of immune cell biology for drug discovery. One promising class of cell-based treatments is Chimeric Antigen Receptor T (CAR-T) cell therapies, which take advantage of... Read more

  • Gnotobiotic Mouse Technology: An Illustrated Guide (Book Review)

    A recently published illustrated manual on gnotobiotic mouse technology could be a great help to developing common standards in the germ-free research community. Chriss J. Vowles, Natalie E. Anderson, and Kathryn A. Eaton of the University of Michigan have produced a thorough reference in Gnotobiotic... Read more