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Advanced Preclinical Models for Immunology, Oncology and Infectious Disease

Berlin: October 12
Zürich: October 14
Vienna: October 16
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  • You say microbiota, I say microbiome: The 8 word guide to the microbiota

    In a recently published article, The vocabulary of microbiome research: a proposal, authors Marchesi and Ravel propose how scientists should use words associated with microbiome, or rather microbiota, research. This editorial published in Microbiome (2015, 3:31), not only proposes how words like Metataxonomics, Metabonomics... Read more

  • Immune System Engrafted Models FAQ

    Immune system engrafted mouse models are becoming more widely used in immuno-oncology research. As their universe of applications grows, questions invariably arise. Our immune system engraftment experts collected answers to a few of these commonly asked questions. huNOG mice are NOG mice engrafted with... Read more

  • Obstacles to efficacy testing of biologic therapies in mice - anti-drug antibody development

    Immunogenicity can obscure efficacy Biologic drugs such as monoclonal antibodies or RNA therapies can trigger immune reactions (immunogenicity) upon treatment. Such immune reactions can result in toxicity. Aside from potential safety problems, the immune reaction can also reduce the efficacy of the biologic drug.... Read more

  • Meeting report: Tumor Models Boston 2015

    The Tumor Models Boston 2015 meeting brought together researchers from North America, Europe and Asia to discuss the application of models to cancer research. The small meeting provided excellent networking and discussion opportunities. Perhaps the most interesting aspect of the meeting was the clear... Read more

  • Mouse model helps accelerate development of new Alzheimer's therapies

    The majority of the drugs approved by the FDA for treatment of cognitive symptoms in Alzheimer's disease (AD) patients are cholinesterase inhibitors and include drugs such as donepezil, galantamine, and rivastagimine. However, the tolerated doses of cholinesterase inhibitors, such as donepezil, produce only partial improvement... Read more

  • Using CRISPR to change "A" to "T" and "C" to "G"

    CRISPR. The use of this acronym has become ubiquitous in the life sciences. For those who don't know, CRISPR stands for Clustered Regularly Interspersed Palindromic Repeats. We hear people talking about it in the context of gene editing of cell lines and animal models. There... Read more

  • Unraveling Rare Disease: Taconic's Integrated Solution Supports Vici Syndrome Research

    Rare diseases often have a genetic component, so the ability to model a genetic modification and study it in vivo is vital to understanding the disease's mechanisms and identifying therapies. As a leader in the custom development of genetically modified models, Taconic Biosciences is committed... Read more

  • Taconic Biosciences Product Highlight - The Knockout Mouse Repository (KOR)

    The Taconic Biosciences Knockout Mouse Repository's more than 4,100 lines provide academic and commercial researchers worldwide with unparalleled access to fully licensed knockout mouse models. This repository offers the scientific community immediate access to expertly derived, highly valuable research tools that rapidly accelerate translational... Read more