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Exercise as a Lens to View the Microbiome and Intestinal Health

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Inflammatory Bowel Disease in Humanized Mice

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  • Are Humanized Mice the Future of Oncology Models?

    Oncologists are up against the limits of cell cultures and xenografts in applied research. Are humanized mice the solution? In an article discussing the challenge of tumor heterogeneity, Drug Discovery News (DDN) laid out several factors which contribute to heterogeneity and which complicate the clinical... Read more

  • The Dirty Future of Immunology Animal Models

    When discrepancies in immune response arise between animal models and humans, some investigators are quick to question the adequacy of laboratory mice as a proxy for human subjects. Two collaborative studies, published in Nature and Cell Host & Microbe, suggest that animal model microbiome and... Read more

  • Choosing a Health Standard for Your Model

    Taconic produces rodent models at several different health standards. How do you know which health designation to choose when ordering animals? Taconic rodent models are available at multiple health standards, enabling researchers to choose the most appropriate model for their studies. These five health standards... Read more

  • Preclinical Immuno-Oncology Animal Models

    Immuno-oncology - triggering a patient's own immune system to attack their cancer - is sweeping through all levels of oncology research, from academia to biotech and pharma. Silicon Valley mogul Sean Parker, co-founder of Napster and first president of Facebook, pledged $250 million to set... Read more

  • Patient-derived Xenografts of Hematological Malignancies Webinar Review

    Dr. Julia Schueler of Oncotest presented a webinar exploring her work with patient-derived xenografts (PDX) of hematological malignancies as model systems for drug development and tumor biology research. PDX models of hematological origin provide the same advantages as solid tumor PDX models, such as preserving... Read more

  • Review: Humanized Mouse Model Research Symposia

    Humanized mouse models are critical tools for basic research, modeling of certain human-specific infectious diseases, efficacy testing of immunotherapy approaches, and safety assessment for large molecule therapeutics. Taconic Biosciences recently hosted the symposium series "Advanced Preclinical Models for Immuno-oncology and Infectious Disease" in several European... Read more

  • Production of Germ-Free Mice: Then and Now

    On September 26, 1949, Life Magazine showed the world "a strange, new sterile laboratory at Notre Dame", where animal care technicians in diving suits submerged themselves in germicidal tanks, and animals were raised in sealed environments. Scientists were curious whether germ-free organisms would live longer,... Read more

  • Patient-Derived Xenografts Q&A with Dr. Els Hermans

    Dr. Els Hermans, whose work on the Trace platform at KU Leuven is streamlining the oncology R&D pipeline, presented a webinar focused on the application of patient-derived xenograft models (PDX) in translational cancer research. Her presentation on use of PDX models to close the gap... Read more