Colitis Animal Models in IBD Research

Tuesday, February 14 at 11 a.m. ET

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The Real Impact of Rodent Diet on Microbiome and Gut Health Research

Thursday, March 23 at 11 a.m. ET

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  • Key Immunology Mouse Models in History

    While the field of immunology has origins that date back to the 1500s, the field gained significant ground with the expanded use of mouse model systems. Fundamental discoveries elucidated in mouse models over the past 50 years are beginning to yield major breakthrough treatments for... Read more

  • CNV Psychiatric Disease Models Q&A

    Dr. Michael Didriksen, whose work with Lundbeck Pharmaceuticals is bridging preclinical and clinical schizophrenia and psychosis science, presented a webinar focused on the application of three novel psychiatric disease models, all carrying high-risk genetic copy number variations (CNVs). His presentation on the research applications of... Read more

  • Fecal Microbiota Study Links Parkinson's Disease and the Microbiome

    In a recent Cell publication, a team led by Timothy Sampson and Sarkis Mazmanian of Caltech showed that gut microbiota can promote inflammation of neurons and motor deficits in a human α-synuclein mouse model of Parkinson's disease. Connecting Parkinson's Disease and the Microbiome Emerging data... Read more

  • Generating EAE Mouse Models of Multiple Sclerosis

    Experimental Autoimmune Encephalomyelitis (EAE) is a widely-accepted model of demyelinating diseases, such as multiple sclerosis (MS). How can you most efficiently generate EAE mouse models of multiple sclerosis and which mouse strains work best for this application? Although the exact details are not understood, the... Read more

  • How is the Gut Microbiome Established?

    Research isolating the key factors impacting establishment of an individual gut microbiome has interesting implications for the future of microbiome therapeutics - and translatable mouse model research. Microbiome population diversity is relatively stable throughout the life of a host organism, returning to a durable, individualized... Read more

  • Versatile Applications of the TNFα Mouse

    Research models are often engineered to help answer a narrow set of experimental questions; however, cross-breedings and other experimental interventions allow investigators to dramatically broaden the utility of transgenic mouse models. This is particularly true for models with strong and relatively easy-to-monitor phenotypes, two properties... Read more

  • Investigating Tau Proteins in Alzheimer's Disease Mouse Models

    Despite tau proteins having essential roles in neurodegeneration and amyloid-mediated neurotoxicity, Alzheimer's disease (AD) therapeutic development has largely focused on amyloid-beta. Recent investigations, in humans and rodent Alzheimer's Disease models, suggest specific tau species might be major pathological contributors to AD progression and, as such,... Read more

  • Microbiome Affects Severity in Mouse Model of Malaria

    Malaria is a serious global health hazard, with 214 million new cases worldwide in 2015 according to the World Health Organization. Infection by Plasmodium species can result in a range of disease severity, from asymptomatic infection through severe disease and death. A comparison between mouse... Read more