Webinar:

Immuno-Oncology in Humanized Mice

Monday, October 17, 2016, 11 a.m. ET

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Symposium:

Advancing Microbiome Research: Microbiome & Disease

Thursday, November 3, 2016
Potomac, MD

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  • What's in a Name? Origins of the CIEA NOG mouse®

    The CIEA NOG mouse® is often referred to as an ideal mouse for engraftment of foreign (especially human) cells. The high rates of engraftment make NOG mice a preferred choice for patient-derived xenografts and humanized immune system mice studies. What special properties make the NOG... Read more

  • Modeling Proprioception

    NPR recently published "How A 'Sixth Sense' Helps Simone Biles Fly, And The Rest Of Us Walk", that explored proprioception - the sense of the relative position of neighboring parts of the body - with a story on children with a rare mutation in a... Read more

  • Biotechnology Patents and Genetically Modified Organisms

    How do biotechnology patents affect the generation, use and distribution of genetically modified organisms, such as knockout mice or transgenic animal models? What is a licensing agreement and what are the implications of licensing (or not licensing) methods and technologies used in biomedical research? Can... Read more

  • Ensuring Sterile Feed for Germ-Free Mice

    With the increase in institutions that are initiating microbiome studies comes an increase in demands for sterile support materials. Setting up and maintaining isolators to breed and perform studies with germ-free mice is a challenge. There are a number of ways that a biological contaminant... Read more

  • Copy Number Variation, Microdeletion, and Disease

    Copy number variations (CNVs) are duplications and deletions to large (~5kb-5mb) genomic regions found in varying degrees within the human population. These duplications and deletions significantly contribute to human genetic diversity and can dramatically affect gene-dosage. Recently, pathologic and highly-penetrant CNVs have been identified in... Read more

  • WHAT IS THE MICROBIOME?

    The microbiome is the collection of microorganisms living in and on an organism, such as a human or mouse. Interest in the microbiome is increasing due to a clearer understanding of the its impact on a number of different physiological systems, as well as the... Read more

  • Alzheimer's Treatment Decreases Plaques, Improves Cognition

    Researchers at Biogen published a pivotal Phase 1b clinical study of an Alzheimer's treatment showing not only a decrease in plaques when the monoclonal antibody aducanumab is administered, but also some cognitive improvement in humans. From the paper: "Antibody-based immunotherapy against Αβ to trigger its... Read more

  • Do Some IBD Treatments Work by Altering the Gut Microbiota?

    An IBD treatment targeting key cytokine components appears to alter the microbiome in mouse models of IBD. What's the connection? Cytokines have been implicated in the pathogenesis of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, and modulation of cytokines is one therapeutic... Read more