129S6

Model Description

• Progenitors of this strain used extensively to establish Embryonic Stem (ES) cell lines (e.g., W4) for the production of targeted mutation (knockout) mice
• Targeted mutation mice developed from 129 agouti ES cell lines can often be maintained with maximum genomic homozygosity by mating chimeras to the 129S6 strain
• Taconic's 129 mice are of the Steel ('S') subline.

Origin: Taconic received 129S6 inbred model stock from GenPharm International from two sublines originating from Dr. Martin Evan's colony in 1992. The mice were derived by embryo transfer in 1993. The resulting offspring were heterozygous at Gpi1 for the 'a' and 'c' alleles. Homozygous Gpi-1c brother x sister mice were selected in the Foundation Colony at F8 and became the common ancestors for all subsequent Taconic breeders. The Taconic foundation colony was at F42 in 2005.

Color: White-bellied Black Agouti

Coat Color Loci: A^w

Genetics:

• Strain Profile: Acy1^s, Akp1^b, Amy1^a, Apoa1^b, Car2^a, Es1^b, Es3^c, Esd^b, Es11^a, Ggc^a, Glo1^a, Got2^b, Gpi1^c, Gpt1^a, Gr1^a, Gus-s^b, H6pd^b, Hbb^d, Idh1^a, Ldr1^a, Mod1^a, Mpi1^b, Neu1^b, Pep3^b, Pgm1^b, Pgm2^a, Pnp^a, Trf^b, Sod1^a
• Immunology: H2^b
• Other: Ptprc^b

Animal Diet: NIH #31M Rodent Diet

Growth Chart

Health Reports/Production Sites

View the production locations(s) and the accompanying current IHMS^TM Health Report and Taconic Health Standard for this model

Phenotyping

• 129SVE Phenotyping procedures and report
• 129S6/SvEv Reproductive Characteristics

Price Table

129SVE (in U.S. Dollars)

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

129SVE-RF (in U.S. Dollars)

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

2010 129S6 European prices

Contact Us or call:

• 888.TACONIC (822.6642)
• Fax: 518.697.3910
• +45 70 23 04 05 (Europe)