B6;SJL Mixed Background
|1349-RD1-F||Hemizygous/rd1 Heterozygous or Wild Type||B6;SJL-Tg(APPSWE)2576Kha|
|1349-RD1-M||Hemizygous/rd1 Heterozygous or Wild Type||B6;SJL-Tg(APPSWE)2576Kha|
|1349-RD1-F||Wild Type/rd1 Heterozygous or Wild Type||B6;SJL-Tg(APPSWE)2576Kha|
|1349-RD1-M||Wild Type/rd1 Heterozygous or Wild Type||B6;SJL-Tg(APPSWE)2576Kha|
Origin: The APPSWE mouse was developed in the laboratory of Karen Hsiao at the University of Minnesota, in association with the Mayo Clinic. This model was created by microinjecting the human APP695 gene containing the double mutation K670N, M671L into B6SJLF2 zygotes using a hamster prion protein cosmid vector. The resultant mice from Founder Line 2576 were backcrossed to C57BL/6. Taconic received stock from the Mayo Foundation in March 1999. Hemizygous males were backcrossed with C57BL/6NTac for derivation by embryo transfer. The colony is maintained by mating hemizygous male mice with B6SJLF1 female mice.
Genetics: Wildtype for Nnt mutation, carries Pde6brd1 mutation
Initial Publication: Hsaio K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science, 274:99-102.
Animal Diet: NIH #31M Rodent Diet
Label License: Conditions of Use for Taconic Transgenic Models™
APPSWE 1349 Survival Study - Sex Influence (PDF file: 20KB)
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