tADMET
A unique and evolving portfolio of translational (humanized & knockout) mouse models, in vitro tools and services for an improved prediction of the Absorption, Distribution, Metabolism, Excretion and Toxicity characteristics of new compounds in humans.

tADMET Components Applications Your Benefits
Humanized and knockout mice of ADMET related genes FRG™ KO Technology Carcinogenicity models tADMET™ Contract Services
  • Drug-drug interactions
  • Human metabolite testing
  • Assessment of bioavailability and clearance
  • PKPD modeling
  • Carcinogenicity testing
  • Infectious diseases
  • Drug Metabolism
  • Toxicity testing
  • Improved drug candidate selection
  • Higher clinical success rates
  • Reduced costs
  • Support drug approval by regulators
  • Support of scientific publications
New Products Latest Publications Free Downloads
  • Scheer N, Roland Wolf C. Xenobiotic receptor humanized mice and their utility. Drug Metab Rev. 2012 Nov 23. [Epub ahead of print]
  • Scheer N, Kapelyukh Y, Chatham L, Rode A, Buechel S, Wolf CR. Generation and Characterization of Novel Cytochrome P450 Cyp2c Gene Cluster Knockout and CYP2C9 Humanized Mouse Lines. Mol Pharmacol. 2012 Aug 23.
  • Review more tADMET™ publications
Learn more about the tADMET™ portfolio with the tADMET™ brochure and the FRG™ KO Technology flyer

All products at a glance

Xenoreceptor Panel Cytochrome P450 Panel Phase 2 Transporter Panel
Knockouts Humanized Knockouts Humanized Humanized Knockouts Humanized
Ahr AHR Cyp1a1/1a2*** CYP1A1/1A2*** UGT1A1*1*** Bcrp  
Car CAR Cyp2c CYP2C9   Mdr1a  
Pparα   Cyp2d CYP2D6   Mdr1a/b  
Pxr PXR* Cyp3a (7-gene) CYP3A4/3A7   Mdr1a/b-Bcrp  
Pxr-Car PXR-CAR Cyp3a (8-gene) Liver CYP3A4   Mrp1  
Pxr-Car-Ahr PXR-CAR-AHR**   Gut CYP3A4   Mrp2 MRP2**
Pxr-Car-Pparα*** PXR-CAR-PPARα***   Liver & Gut CYP3A4   Oatp1a/1b OATP1B1
    Cyp2c-Cyp2d-Cyp3a**       OATP1B3
            OATP1B1-1B3***
          Oct1/2  

Composite models (humanized) Carcinogenicity models Related models
PXR-CAR-CYP3A4/3A7 rasH2 HRN™
PXR/CAR/CYP3A4/3A7/CYP2D6** TSG-p53 (N5) Mouse HRN™ nude
PXR/CAR/CYP3A4/3A7/CYP2D6/CYP2C9***    
FRG™ KO technology offered in collaboration with Yecuris™ Corporation
Humanized liver models Human hepatocytes Reagents

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*** Coming soon