Emerging Models

The Taconic Emerging Models program offers access to developing models sponsored by various Principal Investigators. Animal Models enrolled in the Taconic Emerging Models program are listed below in order by sponsor, gene of interest, and model number. To place an order, please click on the order button above. Some Emerging Models require execution of Material Transfer Agreements (MTAs) before orders may be placed. Please check the individual model pages for that information. For information on how to place an order or regarding MTAs, please contact Taconic Customer Service.

NIAID Exchange Models	TaconicArtemis Emerging Models - Deleter Strains and KinaseSwitch Models
TransADMET Models	Central Institute for Experimental Animals and In-Vivo Science International Sponsored Emerging Model
Ludwig Institute Sponsored Emerging Model	The ALS Association Sponsored Emerging Model
PhysioGenix Sponsored Emerging Model	Light Producing Transgenic Animal Models
University of Cambridge Sponsored Emerging Models	Discontinued Emerging Models

NIAID Exchange Models Available From Taconic

NOTE: Health impact statement for IBU46, which houses the NIAID Emerging Models (except line 004227)

Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
B10.Q/Ai	B10.Q	4059	Immunology	NIAID Schwartz
CCR1tm1	C57BL/6NTac	4087-M	Immunology	NIAID Schwartz
TgN(TCRDO11.10) Rag2tm1	B10.D2	4091-MM	Immunology	NIAID Schwartz
TgN(TCRCyt5CC7-I) Rag2tm1	B10.A/Ai	4094-MM	Immunology	NIAID Schwartz
gamma Ctm1 Rag2tm1	C57BL/10 x C57BL/6	4111-MM 4111-MT	Immunology	NIAID Schwartz
TgN(TCRP14 LCMV) Rag2tm1	C57BL/10 x C57BL/6	4113-MM	Immunology	NIAID Schwartz
TgN(TCRP14 LCMV) TCRAtm1Mom	C57BL/6	4138-MM	Immunology	NIAID Schwartz
Abbtm1 TgN(HLADR4)	C57BL/6	4149-MM	Immunology	NIAID Schwartz
CX3CR1tm1	C57BL/6NTac	4167-M	Immunology	NIAID Schwartz
TgN(OT-I) Rag1tm1	C57BL/6	4175-MM	Immunology	NIAID Schwartz
IL4Ratm1	Balb/cJ	4177-M	Immunology	NIAID Schwartz
TgN(Cd4-Cre)	C57BL/6	4196-M	Immunology	NIAID Schwartz
TgN(Lck-Cre)	C57BL/6	4197-M	Immunology	NIAID Schwartz
flt-3Ltm1Imx	C57BL/6	4207-M	Immunology	NIAID Schwartz
H-2Kbtm1 H-2Dbtm1	C57BL/6Ji	4215-MM	Immunology	NIAID Schwartz
H-2Kbtm1	C57BL/6Ji	4216-M	Immunology	NIAID Schwartz
H-2Dbtm1	C57BL/6Ji	4217-M	Immunology	NIAID Schwartz
TgN(DO11.10) Rag2tm1	BALB/c	4219-M	Immunology	NIAID Schwartz
p47 phox KO	B6.129	4227-M	Immunology	NIAID Schwartz
Tg(OT-II.2a) Rag1tm1Mom	C57BL/6	4234-MM	Immunology	NIAID Schwartz
Nos2tm1	C57BL/6	4236-M	Immunology	NIAID Schwartz
TgN(LTH-1)	C57BL/6	4245-C	Immunology	NIAID Schwartz
IL15tm1Imx	C57BL/6	4269-M	Immunology	NIAID Schwartz
[TGN]CARΔ-I [TgN] DO11.10	BALB/c	4285-MM	Immunology	NIAID Schwartz

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TaconicArtemis Emerging Models

TaconicArtemis Deleter Strains models
Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
Gt(ROSA)26Sortm9(cre/Esr1)Arte	C57BL/6	6466-M	Cre-ERT2	TaconicArtemis
Gt(ROSA)26Sortm16(Cre)Arte	C57BL/6NTac	6467-T	Cre Deleter	TaconicArtemis
Tg(ACTB-Flpe)2Arte	C57BL/6NTac	7089-M	Flp Deleter	TaconicArtemis

TaconicArtemis KinaseSwitch models
Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
Btk	C57BL/6	9723	Kinase studies, immunology, oncology	TaconicArtemis
EphB4	C57BL/6	7742	Kinase studies, neuroscience, oncology	TaconicArtemis
Pdgfrb	C57BL/6	9070	Kinase studies, diabetes, oncology	TaconicArtemis
Rps6kb1	C57BL/6	8026	Kinase studies, neuroscience, metabolic diseases, oncology	TaconicArtemis

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TransADMET Models Sponsored by TaconicArtemis and CXR Biosciences

Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
Nr1i2tm3Arte Nr1i3tm1.1Arte	C57BL/6	8222	ADMET	TaconicArtemis and CXR Biosciences
Nr1i2tm1(NR1I2)Arte Nr1i3tm1(NR1I3)Arte	C57BL/6	8223	ADMET	TaconicArtemis and CXR Biosciences

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Central Institute for Experimental Animals and In-Vivo Science International Sponsored Emerging Model

Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
Prkdcscid Il2rgtm1Sug	NOG.Cg	NOG	Oncology, Infectious Disease, Immunology, Humanization	Central Institute of Experimental Animals and In-Vivo Science International

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Ludwig Institute Sponsored Emerging Model

Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
TNFtm1	B6.129	1921-M		Ludwig Institute Ritter

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The ALS Association Sponsored Emerging Model

Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
TgN(SOD1G93A)L26H	NTac:SD	2148-T 2148-W	ALS Research	The ALS Association

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PhysioGenix Sponsored Emerging Model

Gene(s) of Interest	Background Strain	Taconic Model Number	Field of Application	Sponsoring Institution & Investigator
	T2DN/Mcwi	T2DN	Diabetic Nephropathy	PhysioGenix: Dahly-Vernon

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University of Cambridge Sponsored Emerging Models

Each of the below NOD Congenic models are sponsored by the University of Cambridge, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory. These lines are $45/mouse for 3-5 week old mice and $60/mouse for 6-8 week old mice.

Chromosome(s) of Interest	Gene(s) of Interest	Taconic Model Number	Related Publications
4	<Idd9.1> <Idd9.2> <Idd9.3>	905 This line will be discontinued in the future. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals.
1	<Idd5r444>	1094	Diabetes 2000 Oct;49:1744-1747
3	<Idd3r450>	1098	Genome Res 2000 Apr;4:446-453
4	<Idd9.3>	1106 This line will be discontinued in the future. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals.	Immunity 2000 July;13:107-115
3 & 4	<Idd3/17/10/18> <Idd9r1>	1112 This line will be discontinued in the future. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals.	Immunity 2000 July;13:107-115
3	<Idd3/10/18/r323>	1538 This line will be discontinued in the future. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals.	J Immunol 1997;159:1835-1843
4	<Idd9.1>	1565 This line will be discontinued in the future. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals.
4	<Idd9.2>	1566
1	<Idd5.1> <R193>	2193	J Immunol *173*:164-173
1	<Idd5.1> <R193>	2574 This line will be discontinued in the future. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals.	J Immunol *173*:164-173
	<Idd5> <Idd3>	6109
3	<Idd10> <Idd18>	7754

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Emerging Models that are no longer available or have been replaced

Gene(s) of Interest	Background Strain	Taconic Model Number	Disposition	Sponsoring Institution & Investigator
BALB/c-plgRtm1	BALB/c	3767	No Longer Available	Albany Medical College Metzger
C57BL/6-plgRtm1	C57BL/6	3768	No Longer Available	Albany Medical College Metzger
Rag2tm1 TgN(N15)	B6;129S6	421	No longer available	Dana Farber Reinherz
Rag2tm1 TgN(AND)	STOCK	422	No longer available	Dana Farber Reinherz
Igg3tm1	BALB/c	632	No longer available	Case Western Schreiber
Pik3r1tm1	C57BL/6 N7	725	No longer available. N12 model available from RIKEN	Keio University Koyasu
Pik3r1tm1	BALB/c N7	738	No longer available. N12 model available from RIKEN	Keio University Koyasu
Chromosome of Interest 4	Idd9r11	907	No longer available, replaced with Model 1566	University of Cambridge Todd
Chromosome of interest 1		974	No Longer Available	University of Cambridge Todd
Pik3r1tm1	C57BL/6	1077-M	No longer available. Now available from RIKEN	Keio University Koyasu
Pik3r1tm1	BALB/C	1078-M	No longer available. Now available from RIKEN	Keio University Koyasu
Chromosome of interest 1		1092	No longer available	University of Cambridge
Idd54467	NOD.B6	1095	Now available as Model 2574	University of Cambridge Todd
<Idd10> <Idd18r2>	NOD.B6	1101	No longer available; replaced with model 7754	University of Cambridge
Chromosome of Interest 4	<Idd9r28>	1104	Now available as Model 905	University of Cambridge Todd
Chromosome of Interest 4	<Idd9r11>	1105	Now available as Model 1566	University of Cambridge Todd
Chromosome of interest 17	<H2g7>	1107	No Longer Available	University of Cambridge
17	<H2b>	1108	No longer available	University of Cambridge
H2h4	NOD.B10	1109	No longer available	University of Cambridge Todd
Idd3 and Idd5	NOD.B6	1111 1591	No longer available	University of Cambridge Todd
TgN(APPSWE) 2576	B6;SJL	1349	Available as Commercial Model 1349	Mayo Clinic Stoddard
TgN(HO-1-luc)	FVB	1514-M	No longer available	Xenogen Campbell
Abbtm1 Tlr4<Lps-del>Sic11a1<a>	STOCK	1517	No longer available	Kansas State University Chapes
1 & 3	<Idd3/5> R450/467	1573	No longer available	University or Cambridge
TgN(iNOS-Luc)X-xen	FVB	1582	No longer available	Caliper Life Sciences
Rag2tm1 TgN(OT-II.2)	C57BL/6	1896-MC	In development as Taconic Transgenic Model Rag2/OT-II. Sign up to receive colony updates.	Keio University Koyasu
Rag2tm1 TgN(OT-I.1)	C57BL/6	2334-MC	In development as Taconic Transgenic Model Rag2/OT-I. Sign up to receive colony updates.	Keio University Koyasu
TgN(Cd-4Cre)	STOCK N2	4214	Now available at N9 Model 4196-M	NIAID Schwartz
Ptgs-1tm1	B6;129P2	5001	Now available as Commercial Model 2180	NIEHS Langenbach
Ptgs-2tm1	B6;129P2	5002	Now available as Commercial Model 2181	NIEHS Langenbach

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