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Emerging Models

Emerging Models

 

The Taconic Emerging Models program offers access to developing models sponsored by various Principal Investigators. Animal Models enrolled in the Taconic Emerging Models program are listed below in order by sponsor, gene of interest, and model number. To place an order, please click on the order button above. Some Emerging Models require execution of Material Transfer Agreements (MTAs) before orders may be placed. Please check the individual model pages for that information. For information on how to place an order or regarding MTAs, please contact Taconic Customer Service.

NIAID Exchange Models Taconic Emerging Models
Taconic tADMET™ Models Central Institute for Experimental Animals and
In-Vivo Science International Sponsored Emerging Model
Ludwig Institute Sponsored Emerging Model The ALS Association Sponsored Emerging Model
Light Producing Transgenic Animal Models The Michael J. Fox Foundation Parkinson's Disease Models
Discontinued Emerging Models

NIAID Exchange Models Available From Taconic

Model Name Nomenclature Taconic Model Number Field of Application Sponsoring Institution & Investigator
B10.Q/Ai B10.D1-H2q/SgAi 4059 Immunology NIAID Schwartz
CCR1 Knockout B6.129S4-Ccr1tm1Gao N10+N5 4087 Immunology NIAID Schwartz
Rag2 Knockout/Transgenic DO11.10 T Cell Receptor B10.D2-Rag2tm1Fwa Tg(DO11.10)10Dlo/AiTac 4091 Immunology NIAID Schwartz
Rag2 Knockout/Transgenic Cyt5CC7 T Cell Receptor B10.A-Rag2tm1Fwa H2-T18a Tg (Tcra5CC7,Tcrb5CC7)lwep 4094 Immunology NIAID Schwartz
Rag2/II2rg Double Knockout B10;B6-Rag2tm1Fwa II2rgtm1Wjl 4111 Immunology NIAID Schwartz
Tcrα Knockout/Transgenic LCMV P14 T Cell Receptor B6.Cg-Tcrαtm1Mom Tg(TcrLCMV)327Sdz 4138 Immunology NIAID Schwartz
Abb Knockout/Transgenic HLA-DR4 B6.129S2-H2-Ab1tm1Gru Tg(HLA-DRA/H2-Ea,HLA-DRB1*0401/H2-Eb)1Kito 4149 Immunology NIAID Schwartz
CX3CR1 Knockout B6.129-Cx3cr1tm1Zm 4167 Immunology NIAID Schwartz
Fpr1 Knockout C57BL/6NTac-Fpr1tm1Gao N6 4169 Immunology NIAID
Rag1 Knockout/Transgenic OT-I T Cell Receptor B6.129S7-Rag1tm1Mom Tg(TcraTcrb)1100Mjb N9+N1 4175 Immunology NIAID Schwartz
II4ra Knockout BALB/cJ-Il4ratm1Sz 4177 Immunology NIAID Schwartz
Cd4-cre Transgenic B6.Cg-Tg(CD4-cre)1Cwi N9 4196 Immunology NIAID Schwartz
Lck-cre Transgenic B6.Cg-Tg(Lck-cre)1Cwi N9 4197 Immunology NIAID Schwartz
Flt3l Knockout C57BL/6-flt3Ltm1Imx 4207 Immunology NIAID Schwartz
H2-Kb H2-Db Double Knockout B6.129P2-H2-Kbtm1 H2-Dbtm1 N12 4215 Immunology NIAID Schwartz
H2-Kb Knockout B6.129P2-H2-Kbtm1 N12 4216 Immunology NIAID Schwartz
H2-Db B6.129P2-H2-Dbtm1 N12 4217 Immunology NIAID Schwartz
Rag2 Knockout/Transgenic DO11.10 T Cell Receptor C.Cg-Rag2tm1Fwa Tg(DO11.10)10Dlo 4219 Immunology NIAID Schwartz
Rag1 Knockout/Transgenic OT-II T Cell Receptor B6.129S7-Rag1tm1Mom Tg(TcraTcrb)425Cbn 4234 Immunology NIAID Schwartz
Nos2 Knockout B6.129S2-Nos2tm1MrI N12 4236 Immunology NIAID Schwartz
LTH-1 Transgenic B6.SJL-Tg(Lck-tTA)1Dim N10 4245 Immunology NIAID Schwartz
IL15 Knockout C57BL/6NTac-IL15tm1Imx N5 4269 Immunology NIAID Schwartz
Transgenic D011.10 T Cell Receptor/Transgenic CAR BALB/cJ-Tg(DO11.10)10Dlo Tg(CARΔ-1)1Jdgr 4285 Immunology NIAID Schwartz
Rag2 Knockout/Transgenic LCMV-P14 T Cell Receptor B10.Cg-Rag2tm1Fwa Tg(TcrLCMV)327Sdz 4356 Immunology NIAID Schwartz
SAP/Sh2d1A Knockout B6.129-Sh2d1atm1Pls 8424 Immunology NIAID Schwartz

This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201200029C.

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Taconic Emerging Models

Deleter Strains models
Model Name
 Nomenclature Taconic Model Number
Cre-ERT2 C57BL/6NTac-Gt(ROSA)26Sortm9(Cre/ESR1)Arte 10471
Cre Deleter Gt(ROSA)26Sortm16(Cre)Arte 6467
Flp Deleter Tg(CAG-Flpe)2Arte 7089

KinaseSwitch models
Model Name Background Taconic Model Number Field of Application
Btk C57BL/6 9723 Kinase studies, immunology, oncology
EphB4 C57BL/6 7742 Kinase studies, neuroscience, oncology
Pdgfr-β C57BL/6 9070 Kinase studies, diabetes, oncology
Rps6kb1 C57BL/6 8026 Kinase studies, neuroscience, metabolic diseases, oncology

Other Taconic Emerging Models
Model Name
 Nomenclature Taconic Model Number
B6 Albino A++ C57BL/6NTac-Atm1.1Arte Tyrtm1Arte 11227
HRN™ nude CrTac:NCr-Portm1Wolf Foxn1nu Tg(Alb-cre)21Mgn 9066

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Taconic tADMET™ Models


Model Name Nomenclature Taconic Model Number Field of Application
Pxr-Car Knockout Mouse C57BL/6-Nr1i2tm3Arte Nr1i3tm1.1Arte 8222 ADMET
Humanized PXR-CAR Mouse C57BL/6-Nr1i2tm1(NR1I2)Arte Nr1i3tm1(NR1I3)Arte 8223 ADMET
Cyp3a (7-gene) Knockout Mouse C57BL/6NTac-Del(5Cyp3a57-Cyp3a59)1Arte 8841 ADMET
Humanized CYP3A4/3A7 Mouse C57BL/6-Del(5Cyp3a57-Cyp3a59)1Artetm1(CYP3A4-CYP3A7)Arte 8842 ADMET
Humanized Gut CYP3A4 Mouse FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs Tg(Vil1-CYP3A4)1Ahs 9047 ADMET
Humanized Liver CYP3A4 Mouse FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs Tg(APOE-CYP3A4)A1Ahs 9048 ADMET
Humanized Liver & Gut CYP3A4 Mouse FVB.129P2-Cyp3a13tm1Ahs Del(5Cyp3a57-Cyp3a59)1Ahs Tg(Vil1-CYP3A4)1Ahs Tg(APOE-CYP3A4)A1Ahs 9049 ADMET
Pxr Knockout Mouse C57BL/6-Nr1i2tm3Arte 9100 ADMET
Humanized CAR Mouse C57BL/6-Nr1i3tm1(NR1I3)Arte 9101 ADMET
Car Knockout Mouse C57BL/6-Nr1i3tm1.1Arte 9103 ADMET
Humanized PXR Mouse C57BL/6-Nr1i2tm1(NR1I2)Arte 9104 ADMET
Humanized AHR Mouse C57BL/6-Ahrtm1.1(AHR)Arte 9165 ADMET
Ahr Knockout Mouse C57BL/6-Ahrtm1.2Arte 9166 ADMET
Cyp2c Knock Out Mouse B6-Cyp2ctm1104Arte 9177 ADMET
Cyp2d Knockout Mouse C57BL/6-Del(15Cyp2d22-Cyp2d26)1Arte 9178 ADMET
Humanized MRP2 Mouse C57BL/6-Abcc2tm1(ABCC2)Arte 9179 ADMET
Pxr-Car-Ahr Knockout Mouse C57BL/6-Nr1i3tm1.1Arte Ahrtm1.2Arte Nr1i2tm3Arte 11583 ADMET
Humanized CYP2D6 Mouse C57BL/6-Is(15CYP2D6;Del15Cyp2d22-Cyp2d26)3Arte 11584 ADMET
Humanized PXR-CAR-CYP3A4/3A7 Mouse C57BL/6-Nr1i3tm1(NR1I3)Arte Is(5CYP3A4-CYP3A7;Del5Cyp3a57-Cyp3a59)2Arte Nr1i2tm1(NR1I2)Arte 11585 ADMET
Humanized Liver CYP2C9   11746 ADMET
Learn more about the Taconic tADMET™ program

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Central Institute for Experimental Animals and In-Vivo Science International Sponsored Emerging Model


Model Name Nomenclature Taconic Model Number Field of Application Sponsoring Institution & Investigator
CIEA NOG mouse® NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac NOG Oncology, Infectious Disease, Immunology, Humanization Central Institute of Experimental Animals and In-Vivo Science International
CIEA BRG mouse C.Cg-Rag2tm1Fwa Il2rgtm1Sug/JicTac 11503 Oncology, Infectious Disease, Immunology, Humanization Central Institute of Experimental Animals and In-Vivo Science International

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Ludwig Institute Sponsored Emerging Model


Model Name Nomenclature Taconic Model Number Field of Application Sponsoring Institution & Investigator
TNFtm1 B6.129 1921   Ludwig Institute Ritter

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The ALS Association Sponsored Emerging Model


Model Name Nomenclature Taconic Model Number Field of Application Sponsoring Institution & Investigator
TgN(SOD1G93A)L26H NTac:SD 2148 ALS Research The ALS Association

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Emerging Models that are no longer available or have been replaced


Model Name Nomenclature Taconic Model Number Disposition Sponsoring Institution & Investigator
Rag2tm1 TgN(N15) B6;129S6 421 No longer available Dana Farber Reinherz
Rag2tm1 TgN(AND) STOCK 422 No longer available Dana Farber Reinherz
Igg3tm1 BALB/c 632 No longer available Case Western Schreiber
Pik3r1tm1 C57BL/6 N7 725 No longer available. N12 model available from RIKEN Keio University Koyasu
Pik3r1tm1 BALB/c N7 738 No longer available. N12 model available from RIKEN Keio University Koyasu
Chromosome of interest: 4 NOD.B10-Idd9.1 Idd9.2 Idd9.3 N12 905 Available at Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
Chromosome of Interest 4 Idd9r11 907 No longer available University of Cambridge Todd
Chromosome of interest 1
974 Available from the Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge Todd
Pik3r1tm1 C57BL/6 1077 No longer available. Now available from RIKEN Keio University Koyasu
Pik3r1tm1 BALB/C 1078 No longer available. Now available from RIKEN Keio University Koyasu
Chromosome of interest 1 1092 Available from the Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
NOD.B10-Idd5.1 Idd5.2 Idd5.3   1094 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge
Idd54467 NOD.B6 1095 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge Todd
NOD.B6-Idd3   1098 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge
<Idd10> <Idd18r2> NOD.B6 1101 No longer available University of Cambridge
Chromosome of Interest 4 <Idd9r28> 1104 Now available as Model 905 University of Cambridge Todd
Chromosome of Interest 4 <Idd9r11> 1105 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge Todd
NOD.B10-Idd9.3 line 1106 NOD.B10-Idd9.3 N14 1106 Available from the Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
Chromosome of interest 17 <H2g7> 1107 Available from the Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
17 <H2b> 1108 Available from the Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
H2h4 NOD.B10 1109 Available from the Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge Todd
NOD.B6-Idd3 Idd17 Idd10 Idd18 B10-Idd9 line 1112 NOD.B6-Idd3 Idd17 Idd10 Idd18 B10-Idd9 N6 1112 This line has been discontinued. If you have long term needs for this model, please set up a breeding colony, either at Taconic or at your own facility. Contact us immediately to purchase the necessary breeding animals. To be available from the Type 1 Diabetes Resource at the Jackson Laboratory. Univeristy of Cambridge
Idd3 and Idd5 NOD.B6 1111
1591		 No longer available University of Cambridge Todd
TgN(APPSWE) 2576 B6;SJL 1349 Available as Commercial Model 1349 Mayo Clinic Stoddard
TgN(HO-1-luc) FVB 1514-M No longer available Xenogen Campbell
Abbtm1 Tlr4<Lps-del>Sic11a1<a> STOCK 1517 No longer available Kansas State University Chapes
Chromosome of interest: 3 NOD.B6-Idd3 Idd10 Idd18 N12 1538 Available at Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
Chromosome of interest: 4 NOD.B10-Idd11 Idd9.1 N12 1565 Available at Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
NOD.B10-Idd9.2   1566 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge
1 & 3 <Idd3/5> R450/467 1573 No longer available University of Cambridge
TgN(iNOS-Luc)X-xen FVB 1582 No longer available Caliper Life Sciences
Rag2tm1 TgN(OT-II.2) C57BL/6 1896 In development as Taconic Transgenic Model Rag2/OT-II. Sign up to receive colony updates. Keio University Koyasu
NOD.B10-Idd5.1   2193 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge
Rag2tm1 TgN(OT-I.1) C57BL/6 2334 Available now as Taconic Transgenic Model Rag2/OT-I. Keio University Koyasu
Chromosome of interest: 1 NOD.B10-Idd5.1 N16 2574 No longer available University of Cambridge
BALB/c-plgRtm1 BALB/c 3767 No Longer Available Albany Medical College
Metzger
C57BL/6-plgRtm1 C57BL/6 3768 No Longer Available Albany Medical College
Metzger
Rag2 Knockout/Transgenic LCMV-P14 T Cell Receptor B10;B6-Rag2tm1Fwa Tg(TcrLCMV)327Sdz 4113 Available now as Rag2 Knockout/Transgenic LCMV-P14 T Cell Receptor. NIAID Schwartz
TgN(Cd-4Cre) STOCK N2 4214 Now available at N9 Model 4196-M NIAID Schwartz
p47 phox Knockout B6.129S2-Ncf1tm1Shl N14 4227 No longer available NIAID Schwartz
Ptgs-1tm1 B6;129P2 5001 Now available as Commercial Model 2180 NIEHS Langenbach
Ptgs-2tm1 B6;129P2 5002 Now available as Commercial Model 2181 NIEHS Langenbach
NOD.B-Idd5.1 Idd5.2 Idd5.3 Idd3   6109 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge
NOD.B6-Ptprcb   6908 May be available from the Type I Diabetes Resource at the Jackson Laboratory University of Cambridge
Type 1 Diabetes NOD.B6-Idd10 Idd18 7754 Available at Type 1 Diabetes Resource at the Jackson Laboratory University of Cambridge
T2DN T2DN/Mcwi 7937 Diabetic Nephropathy PhysioGenix: Dahly-Vernon
FatRat™ WH-Mc4rfat1Hubr 10682/11203 No longer available through Taconic Transposagen Biopharma, Jack Crawford

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