Whenever possible, Taconic follows the guidelines set forth by the International Rat Genetic Nomenclature Committee and the International Committee on Standardized Nomenclature for Mice. Standardized nomenclature assists the identification of the desired model. The nomenclature for the line background of the TTM™ lines or Spontaneous Mutant models follows nomenclature guidelines for inbred, congenic, or mixed backgrounds. Nomenclature for transgenic models includes the currently accepted gene name or allele designation, including lab codes to designate the originator of the model.
When necessary, Taconic updates the nomenclature used for models to reflect updated gene names and additional information. To that end, Taconic has changed the nomenclature used for several models, effective immediately on the website and reflected in the 2008 Products and Services Guide. Following is an listing of previous and current nomenclature for all lines that have been changed, with a brief explanation of the reason for the change. Please be assured that the models themselves remain the same. We have just updated the nomenclature used to designate each model.
Please note that for all microinjected models, the gene of interest was previously italicized. That is no longer standard practice, so microinjected model nomenclature is entirely in regular type. That change has not been broken out for each model below.
| Taconic Model Name | Taconic Model Number | Previous Nomenclature | Current Nomenclature | Explanation of Changes |
|---|---|---|---|---|
| ApoB100 | 001004 | B6.SJL-Tg(APOB100) N20+? | B6.SJL-Tg(APOB)1102Sgy N20+? | The transgene allele has been updated to reflect the latest gene name and now also includes a founder line and lab code. |
| APPSWE-Tau | 002469 | STOCK Tg(APPSWE)2576Kha Tg(MAPT) JNPL3Hlmc | STOCK Tg(APPSWE)2576Kha Tg(Prnp-MAPT*P301L)JNPL3Hlmc | The Tau transgenic allele was updated to include promoter information and designate the mutant residue. |
| APPSWE-Tau control | 003273 | B6D2(B6SJLF1)/NTac | STOCK | The STOCK designation more correctly refers to the genetic background of this control model. |
| B6 nude | B6NU | B6.Cg/NTac-Foxn1nu NE9 | B6.Cg/NTac-Foxn1nu NE10 | Additional backcross to B6/N performed in 2007. |
| Ccr2 | 003736 | B6.129P2-Ccr2tm1Kuz N10 | B6.129P2-Ccr2tm1Mae N10 | The lab code has been updated. |
| CETP | 001003 | B6;SJL-Tg(CETP) | B6;SJL-Tg(APOA1-CETP)1Dsg | The transgenic allele was updated to include promoter information and now also includes a founder line and lab code. |
| CETP-ApoB100 | 001007 | B6;SJL-Tg(CETP) Tg(APOB100) | B6;SJL-Tg(APOA-CETP)1Dsg Tg(APOB)1102Sgy | The ApoB100 transgene allele has been updated to reflect the latest gene name and now also includes a founder line and lab code. The CETP transgenic allele was updated to include promoter information and now also includes a founder line and lab code. |
| ERKO-β | 001954 | B6.129-Esr2tm1Ksk N9 | B6.129-Esr2tm1Unc N9 | The lab code has been updated. |
| HY | 004051 | B10.Cg-Tg(TcrH-Y)71Vbo N12 | B10.Cg-Tg(TcraH-Y,TcrbH-Y)71Vbo N12 | The transgenic allele was updated to include the most current gene name. |
| RasH2 | 001178 | CB6F1/Jic-TgrasH2@Tac | CByB6F1-Tg(HRAS)2Jic | The genetic background designation has been updated to specifically refer to the CBy subline used. The transgenic allele has been updated to include the most current gene name, and also not includes a founder line and lab code. |
| Tau | 002508 and 001638 | STOCK Tg(MAPT)JNPL3Hlmc | STOCK Tg(Prnp-MAPT*P301L)JNPL3Hlmc | The Tau transgenic allele was updated to include promoter information and designate the mutant residue. |
| Rag2-HY | 004079 | B10.Cg-Rag2tm1Fwa Tg(TcrH-Y )71Vbo N10 | B10.Cg-Rag2tm1Fwa Tg(TcraH-Y,TcrbH-Y )71Vbo N10 | The HY microinjected allele was updated to include the most current gene name. |
| JH | 001147 | C;129(B6)-Igh-Jtm1Dhu N?+N2 | STOCK Igh-Jtm1Dhu N?+N2 | The STOCK designation more accurately refers to the genetic background of this line. |
| APOE2 | 001547 | B6.129P2-Apoetm1(APOE2)Mae N9 | B6.129P2-Apoetm1(APOE*2)Mae N9 | The replaced gene designation was updated to include the most current gene name. |
| APOE3 | 001548 | B6.129P2-Apoetm1(APOE3)Mae N8 | B6.129P2-Apoetm1(APOE*3)Mae N8 | The replaced gene designation was updated to include the most current gene name and targeted mutation reference. |
| APOE4 | 001549 | B6.129P2-Apoetm1(APOE4)Mae N8 | B6.129P2-Apoetm1(APOE*4)Mae N8 | The replaced gene designation was updated to include the most current gene name and targeted mutation reference. |
