Taconic's portfolio of ADME-Tox models and services

Taconic offers a variety of animal models and services useful for your ADME-Tox studies. Taconic Transgenic Models^TM are sold with full research use rights, and include a number of drug transporter knockouts. Combine any of our animal models with surgical services or our contract research offerings for one stop shopping.

Taconic's portfolio of ADME-Tox models and services

Taconic Transgenic Models™	Traditional Animal Models	Surgically Modified Models	Contract Research Solutions
Bcrp Mouse	Sprague Dawley® Rat	Jugular Vein Cannulation	Compound Administration
Mdr1a Mouse	Wistar Hannover GALAS™ Rat	Carotid Artery Cannulation	Interim blood sampling
Mdr1a/b Mouse	ICR mouse	Femoral Artery Cannulation	Clinical observation
Mdr1a/b-Bcrp Mouse	Black 6 Mouse	Femoral Vein Cannulation	Terminal blood collection
HRN™ Mouse	NMRI Mouse	Portal Vein Cannulation	Tissue harvesting
Mrp1 Mouse		Bile Duct with Duodenal Return
Mrp2 Mouse		Telemetry Implants
Oct1/2 Mouse
Pparα Mouse
PXR Mouse

HRN™ Mouse: The Hepatic Reductase Null Mouse, developed by CXR Biosciences, is a conditional knockout of Por, resulting in a mouse that lacks cytochrome P450 activity in the liver. The HRN™ mouse is useful for determining the role of hepatic P450 metabolism in drug disposition. It can provide information on whether parent or metabolite compounds are responsible for observed efficacy or toxicity. This model allows the study of in vivo efficacy using smaller amounts of compound.

PXR Mouse: Pregnane X Receptor (PXR) is a member of the nuclear receptor family of ligand-activated transcription factors that has evolved to protect the body from toxic chemicals. This receptor is activated by a structurally diverse collection of xenobiotics, including several widely-used prescription drugs. PXR stimulates the transcription of multiple genes involved in the detoxification and elimination of these potentially harmful chemicals. This model carries a homozygous disruption of PXR and may be used to study the role of PXR in drug metabolism and excretion.