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scid-beige

SPONTANEOUS MUTANT - T, B & NK CELL DEFICIENT MICE

C.B-17 Background

Model Number	Zygosity	Nomenclature
CBSCBG-F		C.B-Igh-1b/GbmsTac-Prkdc^scid-Lyst^bg N7
CBSCBG-M		C.B-Igh-1b/GbmsTac-Prkdc^scid-Lyst^bg N7

Model Description

The mutations were backcrossed seven generations to the congenic C.B-17 background
Maintained in flexible-film isolators under gnotobiotic conditions
This double mutant model carries the scid mutation which causes a lack of both T and B lymphocytes due to a defect in V(D)J recombination
It also carries the beige mutation which results in cytotoxic T cell and macrophage defects as well as selective impairment of NK cell functions. As a result, SCID-BEIGE mice are potentially an improved model for receipt of xenotransplants and for infectious disease studies
It has also been observed that the C.B-17 SCID-BEIGE strain has a lower incidence of serum Ig relative to the C.B-17 SCID strain

Origin: The scid-beige Spontaneous mutant model was developed by Dr. Anne Croy et al of the University of Guelph in April 1993 by intercrossing C.B-17 from R. A. Phillips to C57BL/6-bg from the Jackson Laboratory. The beige (Lyst bg) mutation was backcrossed seven generations (N7) to a C.B.17 scid spontaneous mutant background from the Ontario Cancer Institute.

Color: Albino

Coat Color Loci: Tyrp1b, Tyrc, Lystbg

Genetics: Refer to the C.B-17 (background strain) for genetic data

Animal Diet: NIH #31M Rodent Diet