Deficient in the gamma chain subunit of the FcgRI, FcgRIII and FceRI receptors
The deleted gamma chain subunit is essential for cell surface expression of these molecules
Macrophages, neutrophils, mast cells, basophils and NK cells are functionally impaired, due to the lack of these Fc receptors
The mice have normal T cell thymic and peripheral T cell development
Useful in determining the role of structurally similar Fc receptors in mediating effector immune responses and studying the pleiotropic role of the γ chain subunit
Exhibit several different types of immunodeficiency making them useful for studies to distinguish the role of the Fc Receptors in antibody-mediated effector responses and to evaluate the contribution of IgG and IgE triggered effector pathways
The mice are fertile and develop normally
These mice carry the H2b haplotype
Genetic Background: C57BL/6 Background
The Fcer1g mouse was developed in the laboratory of J.V. Ravetch in 1993. The model was created by targeting the Fcer1g gene in E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Heterozygotes on a C57BL/6 background were intercrossed to generate homozygous targeted mutation mice. The mice were then backcrossed twelve generations (N12) to C57BL/6J. Taconic received stock in 1996. The mice were derived by embryo transfer in July 1997 and are maintained by incrossing homozygous mice.
Genetics: Carries Nnt mutation
Takai T, Li M, Sylvestre D, Clynes R, Ravetch J. (1994) FcRγ Chain Deletion results in Pleiotrophic Effector Cell Defects. Cell, 76:519-529.