APPSWE-Tau Control

APPSWE Tau Control Mouse Model

Mixed Background

  • Model #
  • Genotype
  • Nomenclature
  • 3273-F
    wt/wt;wt/wt
    STOCK
  • 3273-M
    wt/wt;wt/wt
    STOCK
  • 3273-RD1-F
    wt/wt;wt/wt
    STOCK
  • 3273-RD1-M
    wt/wt;wt/wt
    STOCK
  • Model 3273 contains same strain and stock genetic contribution as 2469 model, but in different proportions
  • Wild type (non-transgenic) for both the APPSWE and Tau transgenes
  • Serves as a control for the APP-Tau Double Microinjected Mouse (2469)
  • Rd1 tested mice (3273-RD1-F and 3273-RD1-M) are wild type or heterozygous for the Pde6brd1 mutation. Genotype shown in the table above refers to the APPSWE and Tau transgenes.

Genetic Background:

C57BL/6, SJL, DBA/2, SW Mixed Background

Origin:

The APPSWE-Tau control model was developed by Taconic to provide an appropriate genetic control for the APPSWE-Tau double microinjected model. The mice are maintained by intercrossing wild type Tau female mice (1638) to wild type APPSWE male mice (1349).


Genetics:

Wild type for Nnt mutation; carries Pde6brd1 mutation


Color:

Various

Species:

Mouse


Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.