- Model 3273 contains same strain and stock genetic contribution as 2469 model, but in different proportions
- Wild type (non-transgenic) for both the APPSWE and Tau transgenes
- Serves as a control for the APP-Tau Double Microinjected Mouse (2469)
- Rd1 tested mice (3273-RD1-F and 3273-RD1-M) are wild type or heterozygous for the Pde6brd1 mutation. Genotype shown in the table above refers to the APPSWE and Tau transgenes.
Genetic Background: C57BL/6, SJL, DBA/2, SW Mixed Background
The APPSWE-Tau control model was developed by Taconic to provide an appropriate genetic control for the APPSWE-Tau double microinjected model. The mice are maintained by intercrossing wild type Tau female mice (1638) to wild type APPSWE male mice (1349).
Wild type for Nnt mutation; carries Pde6brd1 mutation