Abb (H2-Ab1) - Model ABBN12

Constitutive Knock Out

Abb (H2-Ab1) ABBN12 Constitutive Knock Out Mouse Model

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • ABBN12-F
    ko/ko
    B6.129-H2-Ab1tm1Gru N12
  • ABBN12-M
    ko/ko
    B6.129-H2-Ab1tm1Gru N12
  • Contains a disruption of the H2-Ab1 gene
  • Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
  • Useful in transplantation, gene therapy and immunological disease research

Genetic Background:

C57BL/6 Background

Origin:

The Abb mouse was developed in the laboratory of Michael J. Grusby et al. of the Harvard School of Public Health. The model was created by targeting the H2-Ab1 gene in ES-D3 cells and injecting the targeted ES cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to C57BL/6 for 4 generations (N4). Taconic received stock from Tufts University in December 1991, and the mice were backcrossed eight additional generations (N12) to C57BL/6NTac. The mice were derived by embryo transfer and intercrossed to homozygosity.


Genetics:

Wild type for Nnt mutation, carries Pde6brd1 mutation


Color:

Black

Species:

Mouse

Initial Publication:

Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH. (1991) Depletion of CD4+ T-Cells in Major Histocompatibility Complex Class II - Deficient Mice. Science, 253(5026):1417-1420.



Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.