Line 10679 was developed in the laboratory of Chenjian Li at Cornell. The model was created through pronuclear injection of human gene SNCA with the E46K mutation into NTac:SD zygotes. Founder line 70 was bred to NTac:SD. The colony is maintained by mating a wild type female with a hemizygous male to produce hemizygous pups. Taconic received stock from Cornell in 2010 and derived the rats through embryo transfer derivation.
Cannon, J.R., et al., Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to 3 mitochondrial impairment. Exp Neurol. 2012 Nov 12;240C:44-56. doi: 10.1016/j.expneurol.2012.11.007. [Epub ahead of print]
Rats may be cryo-recovered at Taconic. Nonprofit users may access rats for research purposes under a simple label license (no signatures required). For-profit users must first execute a license agreement with Cornell University.
Conditions of Use for Parkinson's Disease Rat Models for Nonprofit Users:
For licensing information, contact:
Cornell Center for Technology Enterprise and Commercialization
Attention: Executive Director
395 Pine Tree Road, Suite 310
Ithaca, NY 14850
Cite: Docket D4184 (LRRK2) and D5203 (alpha-synuclein)