- The mutations were backcrossed seven generations to the congenic C.B-17 background
- This double mutant model carries the scid mutation which causes a lack of both T and B lymphocytes due to a defect in V(D)J recombination
- It also carries the beige mutation which results in cytotoxic T cell and macrophage defects as well as selective impairment of NK cell functions. As a result, scid-beige mice are potentially an improved model for receipt of xenotransplants and for infectious disease studies
- It has also been observed that the C.B-17 scid-beige strain has a lower incidence of serum Ig relative to the C.B.-17 scid strain
Genetic Background: C.B-17 Background
The scid-beige Spontaneous mutant model was developed by Dr. Anne Croy et al of the University of Guelph in April 1993 by intercrossing C.B.-17 from R. A. Phillips to C57BL/6-bg from the Jackson Laboratory. The beige (Lyst bg) mutation was backcrossed seven generations (N7) to a C.B.-17 scid spontaneous mutant background from the Ontario Cancer Institute.
Refer to the C.B-17 (background strain) for genetic data
Coat Color Loci: Tyrp1b, Tyrc, Lystbg