ICR scid

Spontaneous Mutant

ICR scid Spontaneous Mutant Mouse Model

  • Model #
  • Genotype
  • Nomenclature
  • ICRSC-F
    sp/sp
    IcrTac:ICR-Prkdcscid
  • ICRSC-M
    sp/sp
    IcrTac:ICR-Prkdcscid
  • Equivalent to C.B-17 scid's in severity of immunodeficiency, but this outbred background exhibits a significantly reduced incidence of spontaneous Ig production (leakiness)
  • Gains weight faster than the C.B-17 scid which makes the ICR-scid better suited for ascites production from heterohybridomas and as a host for tumor lines
  • Outbred maintained in a specially equipped Isolated Barrier Unit™ (IBU™) where the flora is continuously monitored to assure the absence of specific opportunistic bacteria
  • Mice homozygous for the Prkdcscid mutation lack both T and B cells due to a defect in V(D)J recombination. Therefore, they easily accepts foreign tissue transplants, including human tumors, making them effective models for testing new cancer treatments and as hosts for human immune system tissues (i.e., SCID-hu). SCID mice are also useful for examining the relationship between immunity and disease.

Genetic Background:

ICR Background

Origin:

The ICR scid spontaneous mutant model was developed by the Fox Chase Cancer Center by intercrossing ICR mice to C.B-17-SCID mice. The mice were then backcrossed two generations to a Icr:Ha(ICR) outbred background. Taconic received stock in 1992. The mice were derived by hysterectomy to achieve germ-free status in 1992 prior to introduction into Restricted Flora™ IBUs™.


Coat Color Loci:

Tyrc

Color:

Albino

Species:

Mouse


For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. A minimum 3 gram span is required. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.

n= 100 per sex at RF health standards from US colonies. Data collected 2013-15.
High and Low represent mean +/- 2 standard deviation.
Based on sample size the charts above represents ~90% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Customize this chart by clicking the legend elements, then explore download options by hovering your cursor over the down arrow to the right of the chart title.
Average litter size: 7