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APPSWE - Model 1349

MICROINJECTED
 

B6;SJL Mixed Background

Model Number Zygosity Nomenclature
1349-F Hemizygous B6;SJL-Tg(APPSWE)2576Kha
1349-M Hemizygous B6;SJL-Tg(APPSWE)2576Kha
1349-F Wild Type B6;SJL-Tg(APPSWE)2576Kha
1349-M Wild Type B6;SJL-Tg(APPSWE)2576Kha
1349-RD1-F Hemizygous/rd1 Heterozygous or Wild Type B6;SJL-Tg(APPSWE)2576Kha
1349-RD1-M Hemizygous/rd1 Heterozygous or Wild Type B6;SJL-Tg(APPSWE)2576Kha
1349-RD1-F Wild Type/rd1 Heterozygous or Wild Type B6;SJL-Tg(APPSWE)2576Kha
1349-RD1-M Wild Type/rd1 Heterozygous or Wild Type B6;SJL-Tg(APPSWE)2576Kha
  • Description
  • Health Report
  • Phenotyping

Model Description

  • Carries a transgene coding for the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) precursor protein carrying the Swedish mutation
  • Expresses high concentrations of the mutant Aβ, develops significant amyloid plaques and displays memory deficits
  • Useful for the study of APP expression, amyloid plaque formation, neuronal decline and memory loss associated with Alzheimer's disease (AD) as well as the study of drugs designed for treatment or prevention of Alzheimer's disease
  • NOTE: Premature mortality is an expected phenotype of this line, with mortality of 20% anticipated, particularly in males. Please take this into consideration when deciding upon order size to retain the needed experimental group size
  • Shipping Guidelines: Taconic recommends that customers purchase mice between 10 and 12 weeks of age. Due to a phenotype of sudden death at young ages, Taconic cannot guarantee shipment of mice 9 weeks of age or younger.
  • Pink eyed animals, associated with certain coat colors, and the Pde6brd1 retinal degeneration mutation can cause light sensitivity and/or blindness in some animals. This may impact the results of behavioral testing. Upon request, animals can be screened for eye color, coat color, and/or rd1 homozygosity for an additional fee

Origin: The APPSWE mouse was developed in the laboratory of Karen Hsiao at the University of Minnesota, in association with the Mayo Clinic. This model was created by microinjecting the human APP695 gene containing the double mutation K670N, M671L into B6SJLF2 zygotes using a hamster prion protein cosmid vector. The resultant mice from Founder Line 2576 were backcrossed to C57BL/6. Taconic received stock from the Mayo Foundation in March 1999. Hemizygous males were backcrossed with C57BL/6NTac for derivation by embryo transfer. The colony is maintained by mating hemizygous male mice with B6SJLF1 female mice.

Availability: 
Immediately available

Ordering Note: Between 7 to 12 weeks of age males become aggressive and begin to fight. Male APPSWE mice are shipped in divided Taconic Transit Cages™ with one animal per section. We highly recommend housing APPSWE male mice one per cage.


Color: Various

Genetics: 
Wild type for Nnt mutation, carries Pde6brd1 mutation


Initial Publication: 
Hsaio K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science, 274:99-102.


Animal Diet: NIH #31M Rodent Diet

Licensing Requirements:
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Farms, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred except to obtain embryos or fetuses required for research purposes
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.

Taconic Transgenic Models are produced in Isolated Barrier Unit (IBU™) facilities under MPF™ conditions, and shipped in Taconic Transit Cages (TTC™).