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Carries a transgene consisting of fragments of the human HLA-A*1101 gene and mouse H2-Kb gene which encodes a chimeric class I molecule consisting of the human HLA-A11 leader, α1 and α2 domains ligated to the murine α3, transmembrane and cytoplasmic H2-Kb domains
Expresses the chimeric HLA-A11 class I molecule on the surface of T and B cells
Represents the human HLA-A3 supertype
Useful for infectious disease research, vaccine development and testing, safety and immunogenicity testing as well as research directed towards oncology and autoimmune disorders
Permits identification of epitopes restricted to the HLA-A11 supertype
Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background: CB6F1 Background
Origin: The HLA-A11 model was generated by Pharmexa-Epimmune. The model was created by microinjecting a chimeric transgene combining a fragment of the cDNA clone of the human HLA-A*1101 gene that included leader sequence, α1 and α2 domains ligated to a fragment of the murine H2-Kb gene containing the α3, transmembrane and cytoplasmic domains. This transgene was microinjected into CxB6 zygotes. The resultant mice from Founder Line A11.01 were backcrossed six generations to C57BL/6J. Taconic received stock from Pharmexa-Epimmune in 2008. The line was embryo transfer derived, backcrossed one generation to C57BL/6NTac and then intracrossed to homozygosity. In the production colony, wild type BALB/cAnNTac females are bred to homozygous males on the C57BL/6 background to produce CB6F1 pups.
Color: Black Agouti
Alexander J, Oseroff C, Sidney J, Wentworth P, Keogh E, Hermanson G, Chisari FV, Kubo RT, Grey HM, Sette A. (1997) Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes. J Immunol 159(10):4753-61. Erratum in: J Immunol 1999 162(5):3104