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Constitutive Knockout

Abb/B2m Constitutive Knockout Mouse Model
This line is cryopreserved and requires cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 4080-F
    B6.129-H2-Ab1tm1Gru B2mtm1Jae N17
  • 4080-M
    B6.129-H2-Ab1tm1Gru B2mtm1Jae N17
  • Contains a disruption of the H2-Ab1 gene
  • Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
  • Useful in transplantation, gene therapy and immunological disease research


The Abb/B2m multiple targeted mutation model was generated through the mating of B2m and Abb lines from the Jaenisch laboratory at the Whitehead Institute and the Glimcher lab at Harvard University, respectively. Abb mice at three backcrosses (N3) onto C57BL/6 were mated to B2m at eight backcrosses (N8) onto C57BL/6 in 1992 by Laurie Glimcher. The mice were then backcrossed to N17. Taconic received stock through the NIAID repository and embryo transfer derived the line in 1996. The line is maintained through mating of double homozygotes.


Occasionally, lack of interest forces us to discontinue live production of a Taconic Transgenic Model. Live production of this model ended in 2012. If you have a need for this model, please contact us to discuss available options.


Wild type for Nnt mutation





Initial Publication:

Grusby MJ, Auchincloss H Jr, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH. (1993) Mice lacking major histocompatibility complex class I and class II moleculesProc Natl Acad Sci USA, 90(9):3913-3917.

Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.