Spontaneous Tumor Mice & Rat Models

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SPONTANEOUS TUMOR MICE & RAT MODELS OVERVIEW

Spontaneous tumor models can be challenging to work with, as tumor development is often inconsistent from animal to animal and may only take place in aged animals. The advantage of cancer genetically engineered models (GEMs) is that the tumors develop de novo in the appropriate tissue, with the appropriate microenvironment. One way to more easily develop a simultaneous study cohort is to collect tumors from the cancer GEM (with or without further in vitro expansion) and implant into wild type mice of the same background strain in a syngeneic tumor experiment.

MODEL# DESCRIPTION
Stat1 Knockout Accelerated and amplified development of chemically-induced and spontaneous tumors.
TSG-p53®* Knockout of the Trp53 tumor suppressor gene predisposes homozygous mice to development of various tumors, primarily lymphomas and sarcomas.
Pirc Rat* Excellent model for study of human familial colon cancer. Contains a truncating mutation in the Apc gene at a site corresponding to the human mutation hotspot region of the gene. Heterozygotes develop multiple tumors in the small intestine and colon by 2-4 months of age.
Invasive Lobular Breast Cancer Model* Tissue-specific conditional knockout of Cdh1 (E-cadherin) and Trp53 in mice induces metastatic mammary carcinomas that resemble human invasive lobular carcinoma (ILC), the second most common type of primary breast cancer. Females develop multiple skin and mammary tumors with a median latency of 214 days according to published reports. Note: that 20-30% of mice will develop non-mammary epithelial tumors.
Brca1-Associated Breast Cancer Model* Conditional mouse mutant with somatic deletion of Brca1 and Trp53 in several epithelial tissues including mammary epithelium. Female mice of this strain show a high incidence of mammary tumors that mimic many aspects of human BRCA1-mutated basal-like breast cancer. ~80% of females develop multiple mammary and skin epithelial tumors with onset between 140 and 280 days according to published reports. Note: that 20-30% of mice will develop non-mammary epithelial tumors.
Floxed Ink4a/Arf Mouse* Contains a targeted mutation of Cdkn2a (Ink4a/Arf) which introduced LoxP sites upstream of exon 2 and downstream of exon 3. Cross with the tissue-specific cre of your choice to develop a tumor model, including ones which development sarcomas, carcinomas, lymphomas, and metastatic melanoma.
Floxed p53 Mouse*Contains a targeted mutation of Trp53 which introduced LoxP sites flanking exons 2 through 10. Cross with the tissue-specific cre of your choice to generate a conditional disruption of the Trp53 tumor suppressor gene, the most commonly mutated gene in human cancers. Conditional deletion avoids the predominance of non-epithelial tumors observed in constitutive Trp53 knockouts.

*Available from Taconic's cryopreserved repository.

CUSTOM SOLUTIONS FOR ONCOLOGY AND IMMUNO-ONCOLOGY RESEARCH

Taconic Biosciences' globally-recognized scientific project managers support your custom model design project from design to delivery. Each custom model design project develops along an agile framework, letting you reassess and retarget your model fluidly as new data becomes available. You can pause or postpone projects at any time, or even "back up" project milestones via cryopreservation.

Model Generation Solutions
& Breeding Services

  • Model Acquisition
  • Transition Mutant to Model
  • Scaled Breeding
  • Specialized Services
  • Distribution

Colony Management Solutions

  • Extensive Health Standard Options
  • True Gnotobiotic Profiles
  • Genetic Monitoring Programs
  • Scientific Leadership & Success Team
  • Custom Solutions for Every Partner

FEATURED RESOURCES FOR SPONTANEOUS TUMOR MICE & RAT MODELS

Syngeneic Mouse Models for Preclinical Immuno-Oncology Research

White Paper

Syngeneic Mouse Models for Preclinical Immuno-Oncology Research

Resources - Taconic Insights

Insight

Preclinical Immuno-Oncology Animal Models

Resources - On Demand Webinar

On-Demand Webinar

The Pirc Rat Model of Human Colon Cancer: From the Epigenetics of Tumor Initiation to the Study of Human Sex Disparities

Resources - Publications Database Icon

PUBLICATION

Synergistic Tumor Suppressor Activity of BRCA2 and p53 in a Conditional Mouse Model for Breast Cancer

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