Quality INSIGHTS

An update on mouse kidney parvovirus

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The kidneys of immunodeficient mice infected with MKPV appear pale and shrunken on gross necropsy. Histology reveals significant fibrosis. Source: Roediger et al. Cell 20181 It's been over 18 months since mouse kidney parvovirus (MKPV) was identified as a novel pathogen causing inclusion body nephropathy and eventually renal failure and even death in immunodeficient mice. Roediger et al. described this finding in an Oct 2018 Cell paper:...  Read More

Joyeux Noël and Revolutions in Medicine

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To our Insights readers, Please accept our sincere gratitude for making Insights so widely read. It has been a delight providing these informative articles over the past few years. Please indulge us as we take a break from our standard format for this year-ending Insight. — The Taconic Biosciences' Insight Team What will you do as we near the end of the year? It's the time when...  Read More

SIOP and Russell & Burch's 3Rs

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R.L. Burch and W.M.S. Russell2 W.M.S. Russell (1925-2006) and R.L. Burch (1926-1996) originated the concepts of replacement, reduction, and refinement, which they published in their 1959 book, The Principles of Humane Experimental Technique (Principles)1. The Principles was presented not as the final word of this science, but as a foundation for future developments. The 3Rs, as Russell and Burch first called them, were put forward not just...  Read More

Mouse Kidney Parvovirus (MKPV) - A New Mouse Pathogen

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The kidneys of immunodeficient mice infected with MKPV appear pale and shrunken on gross necropsy. Histology reveals significant fibrosis. Source: Roediger et al. Cell 20181. A consortium of researchers from Australia and the US has announced the discovery of a novel mouse parvovirus, named mouse kidney parvovirus or MKPV. They report this highly infectious pathogen causes inclusion body nephropathy (a type of kidney disease) and eventually renal...  Read More

How Animal Model Handling Affects Your Research

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Researchers who regularly work with mice and rats understand that incorrect handling practices creates unnecessary stress for the animal. If one is new to working with preclinical animal models, or is introducing a new strain to their work, a quick refresher on the benefits of correct handling procedures could be very useful. Improper Animal Handling Causes Stress Certain stressors that affect mice and rats cannot be avoided....  Read More

Animal Models in Drug Discovery

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The use of animal models in research resulted in the advancement of knowledge for how diseases affect animals and humans. It has also led to the effective treatment of disease symptoms or in many cases disease cures. There are a wide variety of animal models used in drug discovery including, but not limited to Drosophila, C. elegans, mice, rats, rabbits, dogs, cats and non-human primates. Over the...  Read More

The Drug Discovery Process

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Introducing a new drug to market is a complex and time-consuming process that can cost pharmaceutical companies an average $2.6 billion and ten years of research and development. There are multiple defined stages for this process, each with their own associated challenges, timelines, and costs. This review will discuss the entire process, from target discovery through clinical trials and post-approval monitoring for the development of a new...  Read More

Animal Models in Space Research

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On Wednesday, December 5th, the Falcon 9 SpaceX rocket launched to the International Space Station (ISS) carrying 5,600 lbs of supplies; a small portion of which were mice of varying ages2. Animal models have been used in space research since the 1940s, and these ongoing projects help us understand how spaceflight affects health in greater depth. This review will highlight the various animal models that have been...  Read More

Effective Communication Improves Quality

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Let's listen in on a hypothetical conversation between a scientist and their procurement department where communication is being used ineffectively: PROCUREMENT OFFICER seated at desk. Enter a SCIENTIST. SCIENTIST: Order me twenty-four B6 mice. Males and Females. Seven weeks of age. PROCUREMENT: (Thinking to themselves) Same scientist, same number of mice from three months ago, I can just replicate the order. (To Scientist) OK. When do you...  Read More

How Are Animal Models Validated?

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Animal models have led to significant leaps in understanding and advancement in human medicine. They are essential for drug discovery and connecting hypothesis-driven benchwork to the patient. However, scientists have struggled with how to define the value of a given animal model1. Animal Model Validation In 1969, McKinney and Bunney were the first to propose criteria on external validity of animal models, mainly focused on affective disorders2....  Read More