Oncology and Immuno-Oncology INSIGHTS

Taconic's Guide to the AACR Virtual Annual Meeting II

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This year the second part of the American Association for Cancer Research's (AACR) Annual Meeting will be held virtually from June 22nd-24th. While the in-person annual AACR conference attracts over 23,000 researchers in multiple fields, the virtual meeting attendance could be even higher with free online access through AACR's website. Topics that will be discussed throughout the meeting include the latest developments in tumor biology and genetics,...  Read More

Webinar Q&A - Beyond HSCs: Humanized Immune System Models Based on PBMCs and Isolated Immune Cell Subsets

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Dr. Paul Volden recently presented a webinar on humanized immune system mouse models, focusing on engraftment of PBMCs and isolated cell subsets. Taconic has extensive experience with humanized mice, both from internal research as well as many collaborations with external partners. Although hematopoietic stem cell-engrafted models such as the huNOG and huNOG-EXL may be better known, these alternate humanization approaches offer advantages for certain studies. We present...  Read More

Taconic Biosciences Learn at Home Series: Oncology

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With many researchers and laboratory animal professionals under orders to remain at home to limit the spread of coronavirus, we know you may have a bit more time on your hands than usual. To help keep you engaged while working from home, Taconic Biosciences has pulled together a series of educational materials organized around different therapeutic areas. The first track is available now, with additional tracks available...  Read More

Challenges in Models of Myeloid Cell Engraftment in Humanized Mice

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Humanized immune system mice are revolutionary research tools for the development of novel immune cell-targeting oncology therapeutics, but the use of first-generation models such as the huNOG (NOG mice engrafted with human CD34+ hematopoietic stem cells) has been limited for some applications by impaired human myeloid cell differentiation. Several investigators sought to understand the mechanistic bottleneck and identified evolutionary disparities between mouse cytokine growth factors and human...  Read More

Which mouse model is best for engrafting human PBMCs?

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Humanized immune system mice generated by engrafting immunodeficient hosts with human peripheral blood mononuclear cells (PBMCs) have been critical tools for evaluating T-cell dependent immunotherapies. However, novel immunodeficient hosts are demonstrating their ability to extend the utility of PBMC-humanization beyond conventional T-cell focused work. The hIL-15 NOG mouse carries a transgene expressing human IL-15 and, unlike conventional immunodeficient models, has been shown to facilitate human NK cell...  Read More

Benefits of Humanized Mice for CAR-T Immunotherapy Studies

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CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. This type of immunotherapeutic utilizes T cells extracted from patient blood which are subsequently modified to target cancer cells. The modification enables these cells to express the chimeric antigen receptor (CAR) on the cellular surface, directing the CAR T cells to recognize and kill...  Read More

New Drugs and Research for Breast Cancer

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October is National Breast Cancer Awareness Month and there is some good news to share in 2019. Over the last year, three new drugs have been approved by the FDA to treat various forms of the disease, among them an immunotherapy for metastatic or unresectable breast cancer. This Insight will highlight these new drugs and how they act to treat various forms of breast cancer. FDA Approves...  Read More

Video: The Jh mouse permits clinically relevant dosing of immunogenic test articles in syngeneic tumor model systems

photo from Video: The Jh mouse permits clinically relevant dosing of immunogenic test articles in syngeneic tumor model systems

Syngeneic tumor models are important preclinical research tools for immuno-oncology drug discovery. One challenge that researchers may encounter when studying novel therapeutics in syngeneic tumor models is immunogenicity. Biologics can induce an immune response in the host, including the development of anti-drug antibodies (ADA). ADA can prevent determination of efficacy of a biologic drug. One solution to this problem is to perform the syngeneic tumor study in...  Read More

What is a Xenograft?

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The term xenograft refers to a tissue or organ that is derived from a species that is different from the recipient of the specimen. They are powerful research tools in oncology as well as essential for treating wounds in the clinic. This Insight will highlight a few key uses of xenografts and why they are important to research studies. Xenografts in the Treatment of Skin Injuries In...  Read More

Nude Mice, Xenografts, and Treating Baldness

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A recent article published in the Columbia Magazine highlights the work of researcher Angela Christiano and her radical solutions to addressing baldness. Dr. Christiano has been working on studies involving hair loss since 1996, with one of her most notable achievements being the discovery of a 'hairless gene' (HR) in 19981. One of her recent advancements in this field has been the growth of human hair follicles...  Read More