Oncology and Immuno-Oncology INSIGHTS

Benefits of Humanized Mice for CAR-T Immunotherapy Studies

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CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. This type of immunotherapeutic utilizes T cells extracted from patient blood which are subsequently modified to target cancer cells. The modification enables these cells to express the chimeric antigen receptor (CAR) on the cellular surface, directing the CAR T cells to recognize and kill...  Read More

New Drugs and Research for Breast Cancer

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October is National Breast Cancer Awareness Month and there is some good news to share in 2019. Over the last year, three new drugs have been approved by the FDA to treat various forms of the disease, among them an immunotherapy for metastatic or unresectable breast cancer. This Insight will highlight these new drugs and how they act to treat various forms of breast cancer. FDA Approves...  Read More

Video: The Jh mouse permits clinically relevant dosing of immunogenic test articles in syngeneic tumor model systems

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Syngeneic tumor models are important preclinical research tools for immuno-oncology drug discovery. One challenge that researchers may encounter when studying novel therapeutics in syngeneic tumor models is immunogenicity. Biologics can induce an immune response in the host, including the development of anti-drug antibodies (ADA). ADA can prevent determination of efficacy of a biologic drug. One solution to this problem is to perform the syngeneic tumor study in...  Read More

What is a Xenograft?

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The term xenograft refers to a tissue or organ that is derived from a species that is different from the recipient of the specimen. They are powerful research tools in oncology as well as essential for treating wounds in the clinic. This Insight will highlight a few key uses of xenografts and why they are important to research studies. Xenografts in the Treatment of Skin Injuries In...  Read More

Nude Mice, Xenografts, and Treating Baldness

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A recent article published in the Columbia Magazine highlights the work of researcher Angela Christiano and her radical solutions to addressing baldness. Dr. Christiano has been working on studies involving hair loss since 1996, with one of her most notable achievements being the discovery of a 'hairless gene' (HR) in 19981. One of her recent advancements in this field has been the growth of human hair follicles...  Read More

Skin Cancer Detection and Prevention

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With most of the United States experiencing warmer weather, increased sun exposure can lead to an increased risk of developing skin cancer. There are more new cases of skin cancer in the US each year than breast, prostate, lung, and colon cancers combined. The most dangerous form of skin cancer is melanoma, which if left untreated can metastasize to other locations within the body1. Detecting Skin Cancer...  Read More

Video: Genetic Background in Syngeneic Models

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Through this excerpt from Taconic Biosciences' Webinar, "Advanced Toolkit For Syngeneic Tumor Modeling in Mice," Dr. Philip Dubé considers the role of genetic background when identifying the proper syngeneic model as well as the importance of validating substrain and specific cell line. Syngeneic models depend on the implanted tumor cell not being rejected by the immune system; it is crucial that cell lines are genetically matched to...  Read More

Metastatic Prostate Cancer Modeling with Humanized Mice

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Prostate cancer will likely remain among the leading causes of cancer-related deaths in men until improved therapies for advanced metastatic disease become available. According to Dr. Steve Kregel, a postdoctoral researcher working with Dr. Arul Chinnaiyan at the University of Michigan, a key barrier to improving prostate cancer therapies is the woefully inadequate models of metastatic disease used in preclinical drug testing. At the 2019 American Association...  Read More

Studying T Cell Distribution in Syngeneic Tumor Models

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In a recent article in The Journal of Pharmacology and Experimental Therapeutics, Khot et al. examined the pharmacokinetics (PK) of exogenously administered T cells in a syngeneic tumor model. As immuno-oncology therapeutics expand into cell-based therapies, such as CAR-T cells, this type of research is needed to support their development. Khot et al. provide valuable insight into the PK of T cell-based therapeutics in this new paper....  Read More