Resuscitation Fluid Composition May Improve Sepsis Outcomes

Resuscitation Fluid Composition May Improve Sepsis Outcomes While modern medicine has done little to improve the mortality rates from severe sepsis, modifications in resuscitation fluid composition may prevent disease progression and improve outcomes.

Researchers at McMaster University recently demonstrated that altering the concentrations of gluconate and acetate in resuscitation fluid impacts both hepatic cytokine production and leukocyte recruitment in a C57BL/6 mouse model of sepsis.

"Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis" was published in Intensive Care Medicine Experimental on January 19.

The US Center for Disease Control's National Center for Health Statistics estimates that based upon information collected for billing purposes, sepsis-related hospitalizations increased from 621,000 in the year 2000 to 1,141,000 in 2008.

taconic biosciences presentationWatch Dr. Thomas Grittith's talk from the Microbiome Research Symposium:

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