Inflammation INSIGHTS

Webinar Q&A — Genetically Engineered Mouse Colitis Models for Preclinical Drug Development

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Dr. Philip Dubé of Taconic Biosciences presented a recent webinar on genetically engineered models (GEMs) of colitis, which are widely used for preclinical research on inflammatory bowel disease (IBD). Although a wide array of GEM colitis models exist, Dr. Dubé focused on a few models which are both most commonly used and most useful for drug discovery. He discussed the relevance of the disease mechanism in each...  Read More

Planning for Success with NASH mice: proper care and acclimation

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Nonalcoholic steatohepatitis, also known as NASH, is categorized by liver inflammation and fibrosis due to a buildup of fat in the liver. It represents a more severe form of nonalcoholic fatty liver disease (NAFLD), which currently has no approved pharmaceutical treatment. There are various types of mouse models used to study NASH, including diet-induced (both high fat and nutrient-deficient diets), chemically-induced, and genetic models. Of these, high...  Read More

Taconic Biosciences Learn at Home Series: Inflammatory Bowel Disease (IBD)

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With many researchers and laboratory animal professionals under orders to remain at home to limit the spread of coronavirus, we know you may have a bit more time on your hands than usual. To help keep you engaged while working from home, Taconic Biosciences has pulled together a series of educational materials organized around different therapeutic areas. This is the second track in our series. Learn at...  Read More

The Translational Relevance of IBD Mouse Models

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Many animal models have been developed to study inflammatory bowel disease (IBD), and they remain in general use for screening of potential new therapies. But a recent review article questions the relevance of many of these models, citing evidence that they may not accurately predict therapeutic response in patients. Background: Types of Rodent Colitis Models Colitis models are commonly grouped into three categories: Chemically-induced colitis: Chemicals such...  Read More

Webinar Q&A — Validated Il10 Knockout Models for IBD Research

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Dr. Philip Dubé recently presented a webinar on validated Il10 knockout mouse models for IBD research. He gave an overview of research in this area and presented new data on these models from studies done by Boehringer Ingelheim and Incyte. Due to time constraints, many of the questions submitted during the webinar went unanswered. We present a full Q&A here. Characterization of Il10 Knockouts Dr. Philip Dubé:...  Read More

Modeling Inflammatory Diseases with NOD2 Knockout Mice

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How the Mucosal Barrier Maintains Homeostasis The mucosal barrier lining the digestive tract is not homogenous and consists of three main components1: An intestinal epithelium, physically separating external environment from the deeper tissues of the body, which contains seven cell types, including stem cells required for epithelial renewal, and some immune cells A mucus layer, composed of mucins and antimicrobial peptides, which forms a protective layer over...  Read More

IBD Severity and Fungi in Microbiome

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Source: Limon et al.1 The microbiome includes not just bacteria, but also fungi, viruses and parasites. While most of the attention has been on bacterial components of the microbiome, new research links a commensal yeast found on human skin to disease severity in inflammatory bowel disease (IBD). Linking Common Fungi with IBD Severity In a new paper published in Cell Host & Microbe, Limon et al. examined...  Read More

Summary of colitis mouse models in IBD research

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Inflammatory bowel diseases (IBD) arise from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been utilized to investigate the underlying mechanisms and develop potential therapeutic strategies. Colitis Animal Models In the table below, we summarize commonly used colitis mouse models and provide key features and tips for...  Read More

Endocannabinoids Prevent Inflammation, Maintain Intestinal Homeostasis

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The inflammatory bowel diseases (IBD) are conditions regulated by a combination of genetic, immune and microbial factors. Although it is a normal component of host defense against pathogens, neutrophil influx to the intestinal lumen is also associated with severe pathology in IBD. In a recent manuscript by Szabady et al., the authors demonstrate a novel role for endocannabinoid compounds in regulating intestinal inflammation by limiting neutrophil migration...  Read More

Marvel Super Heroes Take on IBD

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Takeda Pharmaceuticals has joined forces with Marvel Custom Solutions to develop a graphic novel in which the super heroes have Crohn's disease or ulcerative colitis, and other characters care for family members or patients with Inflammatory Bowel Disease (IBD). As part of a Takeda program called IBD Unmasked, the graphic novel was developed in partnership with Marvel. They consulted with an IBD advisory panel consisting of patients...  Read More