Obesity causes metabolic dysfunctions that lead to debilitating chronic diseases including type 2 diabetes, fatty liver disease, and cirrhosis. Diet-induced obese (DIO) rodents are popular models for studying obesity and pre-diabetes. In 1953, Fenton and Dowling manipulated nutrient composition across a range of refined rodent diets, demonstrating that inbred weanling mice could be induced to obesity on an accelerated timeline1. Since then, DIO mice have become staples... Read More